Murat Oklar, Nilüfer Zorlutuna Kaymak, Burak Tanyildiz, Mehmet Engin Tezcan, Şaban Şimşek
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引用次数: 0
Abstract
Purpose: This study aimed to explore the relationship between treatment adherence, visual acuity, quality of life (QoL), depression, and anxiety levels in individuals with Behçet's uveitis (BU).
Methods: A total of 55 BU patients and 55 healthy controls completed sociodemographic questionnaires, the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), World Health Organization Quality of Life Questionnaire-BREF version (WHOQOL-BREF), Self-reported Questionnaire About Treatment Compliance, and the Morisky Medication Adherence Scale (MMAS). The scores obtained from these scales were analyzed to assess the relationship between treatment adherence, visual acuity, QoL, depression, and anxiety levels.
Results: The results revealed that 36 (65.4%) of the 55 BU patients exhibited depressive symptoms, while 45 (81.8%) of them experienced symptoms of anxiety. Patients with BU demonstrated significantly higher BAI and BDI scores compared to the healthy control group (p < 0.001). Furthermore, the patient group reported lower mean scores across multiple domains of the WHOQOL-BREF questionnaire, including general health, psychological health, social relationships, and environment (p < 0.05). Moreover, a significant association was observed between low treatment adherence and lower values of best-corrected visual acuity (BCVA) (p < 0.05), as well as a higher frequency of uveitis attacks (p = 0.005).
Conclusion: Poor treatment adherence in BU patients has a negative effect on final visual acuity outcomes. Moreover, BU patients experience lower QoL and higher rates of depression and anxiety compared to the healthy control group. These findings highlight the importance of addressing treatment adherence and psychological well-being in the management of BU.
目的：本研究旨在探讨贝赫切特葡萄膜炎（BU）患者的治疗依从性、视力、生活质量（QoL）、抑郁和焦虑水平之间的关系：55名贝赫切特葡萄膜炎患者和55名健康对照者填写了社会人口学问卷、贝克抑郁量表（BDI）、贝克焦虑量表（BAI）、世界卫生组织生活质量问卷--BREF版（WHOQOL-BREF）、治疗依从性自我报告问卷和莫里斯基用药依从性量表（MMAS）。对这些量表的得分进行分析，以评估治疗依从性、视力、QoL、抑郁和焦虑水平之间的关系：结果显示，55 名 BU 患者中有 36 人（65.4%）出现抑郁症状，45 人（81.8%）出现焦虑症状。与健康对照组相比，BU 患者的 BAI 和 BDI 分数明显更高（p p p p = 0.005）：结论：BU 患者治疗依从性差对最终视力结果有负面影响。此外，与健康对照组相比，BU 患者的 QoL 更低，抑郁和焦虑率更高。这些发现凸显了在 BU 的治疗过程中解决治疗依从性和心理健康问题的重要性。
期刊介绍：
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
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