Mucinous Cystadenocarcinoma of the Breast with Bone Metastases: First Case Report and Literature Review.

IF 2 4区 医学 Q3 ONCOLOGY Oncology Research and Treatment Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI:10.1159/000535649
Ying Gong, Xuhua Geng, Yaxin Liu, Ruyan Zhang, Yiqiang Liu, Huiping Li
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Abstract

Introduction: Mucinous cystadenocarcinoma (MCA) of the breast is an extremely rare type of breast carcinoma. Since its biological characteristics, treatment options, and clinical outcomes are unclear, there is a lack of consensus regarding the optimal management of this disease. Thus, our single case report will aid our understanding of its natural history, prognostic factors, and treatment strategies.

Case presentation: We presented a 54-year-old woman with a case of advanced MCA of the breast accompanied by a huge breast mass, lymph node involvement, and distant bone metastases. We diagnosed primary breast MCA through clinical examination, imaging, and immunohistochemical assessments. Subsequently, the patient was treated with a regimen of nab-paclitaxel and bevacizumab, resulting in a significant clinical response. Progression-free survival was maintained during the 6-month follow-up period.

Conclusion: We present the first report worldwide of a rare case of MCA of the breast with a large local mass and bone metastases. Our report adds to the limited literature on this rare breast cancer subtype and highlights the importance of accurate diagnosis and appropriate management of aggressive breast tumors.

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伴有骨转移的乳腺黏液性囊腺癌:首例病例报告和文献综述。
简介乳腺粘液性囊腺癌(MCA)是一种极为罕见的乳腺癌。由于其生物学特征、治疗方案和临床结果尚不明确,人们对这种疾病的最佳治疗方法缺乏共识。因此,我们的病例报告将有助于我们了解其自然史、预后因素和治疗策略:我们报告了一名 54 岁女性的晚期乳腺 MCA 病例,患者伴有巨大乳房肿块、淋巴结受累和远处骨转移。通过临床检查、影像学和免疫组化评估,我们确诊患者为原发性乳腺 MCA。随后,患者接受了纳布-紫杉醇和贝伐单抗治疗方案,取得了显著的临床反应。在6个月的随访期间,无进展生存期得以维持:我们在世界范围内首次报道了一例罕见的乳腺 MCA 病例,该病例伴有大块局部肿块和骨转移。我们的报告补充了有关这种罕见乳腺癌亚型的有限文献,并强调了对侵袭性乳腺肿瘤进行准确诊断和适当治疗的重要性。
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
84
期刊介绍: With the first issue in 2014, the journal ''Onkologie'' has changed its title to ''Oncology Research and Treatment''. By this change, publisher and editor set the scene for the further development of this interdisciplinary journal. The English title makes it clear that the articles are published in English – a logical step for the journal, which is listed in all relevant international databases. For excellent manuscripts, a ''Fast Track'' was introduced: The review is carried out within 2 weeks; after acceptance the papers are published online within 14 days and immediately released as ''Editor’s Choice'' to provide the authors with maximum visibility of their results. Interesting case reports are published in the section ''Novel Insights from Clinical Practice'' which clearly highlights the scientific advances which the report presents.
期刊最新文献
Evaluating the Impact of Age and G8 Assessment on Definitive Treatment Strategies in Elderly Patients with Local Advanced Esophageal Carcinoma. A Comprehensive Review of Epidermal Growth Factor Receptor Mutation Abundance in Non-Small Cell Lung Cancer Treated with Tyrosine Kinase Inhibitors. EGFR plus MET targeted therapies for overcoming treatment resistance in EGFR mutant NSCLC. A Case Report. EGFR-TKI combined with radiotherapy in 105 patients of lung adenocarcinoma with brain metastasis: a retrospective study of prognostic factors analysis. Guidelines: onkopedia - what´s new? Locally advanced rectal cancer.
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