Metastatic Squamous Cell Carcinoma of the Urinary Bladder: Urgent Call for New Therapies.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI:10.1159/000534858

Séverine Banek, Benedikt Hoeh, Cristina Cano Garcia, Florestan Koll, Jens Köllermann, Felix K H Chun, Philipp Mandel, Luis A Kluth, Mike Wenzel

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Abstract

Background: Squamous cell carcinoma (SCC) of the urinary bladder is the most common non-urothelial variant histology. Currently, upfront radical cystectomy is the gold standard for non-metastatic SCC of the bladder. However, several studies have shown that SCC of the bladder is associated with higher aggressiveness and worse survival outcomes, such as progression-free and cancer-specific survival, relative to the urothelial histological subtype. Moreover, metastatic SCC seems to poorly respond to systemic treatments and/or radiotherapy.

Summary: This review summarizes the current knowledge and medical evidence regarding local and systematic treatment of mSCC of the bladder, including a case series of four initially locally advanced and later metastatic SCC patients of our tertiary care hospital.

Key messages: Despite being the second most common variant histology of bladder cancer, current therapies for SCC do not provide satisfactory therapeutic responses.

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转移性膀胱鳞状细胞癌：迫切需要新疗法。

背景：膀胱鳞状细胞癌（SCC）是最常见的非尿道变异组织学。目前，前期根治性膀胱切除术是治疗膀胱非转移性 SCC 的金标准。然而，多项研究表明，与尿路上皮组织学亚型相比，膀胱SCC具有更高的侵袭性和更差的生存结果，如无进展生存期和癌症特异性生存期。此外，转移性SCC似乎对全身治疗和/或放疗反应不佳。摘要：本综述总结了目前有关膀胱mSCC局部治疗和系统治疗的知识和医学证据，包括我们三级医院四例最初为局部晚期、后来为转移性SCC患者的病例系列：关键信息：尽管SCC是膀胱癌中第二常见的变异组织学，但目前的疗法并不能提供令人满意的治疗效果。

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来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.