A walk through the process of translation: eIF4E in resected surgical margins in oral squamous cell carcinoma

Abstract

Head and neck squamous cell carcinoma (HNSCC) represent includes cancers of the oral cavity, larynx, and oropharynx. In relation to Oral squamous cell carcinoma (OSCC), a panel of markers such as p53, eIF4E, Cyclin D 1, MMP-9, and others has been evaluated histopathologically tumor-free/clear surgical margins. The present review summarizes the importance of one of the markers associated with protein translation. eIF4E has a significant role process of tumorigenesis and has the potential to target various molecules associated with Hallmarks of cancer. Lastly, relevant findings from studies done in relation to OSCC have been tabulated.