{"title":"A Study on the Pharmacological Effects and Mechanism of Rhodojaponin III in Rheumatoid Arthritis","authors":"Xiaorong Liu, Shuofu Li, Yin Xu, Wenya Mei, Ribao Zhou","doi":"10.31083/j.fbl2812337","DOIUrl":null,"url":null,"abstract":"Background : Rheumatoid arthritis (RA) is a chronic inflammatory disease with a high rate of disability accompanied by various complications. The pathogenesis of RA is complex with multiple targets and links. This study aims to investigate pharmacological effects and mechanism of Rhodojaponin III in RA. Methods : The bovine type II collagen-induced arthritis (CIA) rat model and tumor necrosis factor-alpha (TNF-α ) induced human umbilical vein endothelial cells (HUVECs) model were constructed. Different concentrations of Rhodojaponin III were utilized for intervention. The progression of CIA was assessed by the arthritis index (AI). Pathological changes in knee joints and synovium were observed. The expressions of angiogenesis-related cytokines were detected. The proliferation, migration, invasion","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioscience-Landmark","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.31083/j.fbl2812337","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
引用次数: 0
Abstract
Background : Rheumatoid arthritis (RA) is a chronic inflammatory disease with a high rate of disability accompanied by various complications. The pathogenesis of RA is complex with multiple targets and links. This study aims to investigate pharmacological effects and mechanism of Rhodojaponin III in RA. Methods : The bovine type II collagen-induced arthritis (CIA) rat model and tumor necrosis factor-alpha (TNF-α ) induced human umbilical vein endothelial cells (HUVECs) model were constructed. Different concentrations of Rhodojaponin III were utilized for intervention. The progression of CIA was assessed by the arthritis index (AI). Pathological changes in knee joints and synovium were observed. The expressions of angiogenesis-related cytokines were detected. The proliferation, migration, invasion
背景：类风湿性关节炎（RA）是一种慢性炎症性疾病，致残率高，并伴有各种并发症。类风湿关节炎的发病机制复杂，具有多靶点、多环节的特点。本研究旨在探讨红豆皂苷 III 对类风湿关节炎的药理作用和机制。方法：构建牛 II 型胶原诱导的关节炎（CIA）大鼠模型和肿瘤坏死因子-α（TNF-α）诱导的人脐静脉内皮细胞（HUVECs）模型。利用不同浓度的红豆皂苷 III 进行干预。用关节炎指数（AI）评估 CIA 的进展。观察膝关节和滑膜的病理变化。检测了血管生成相关细胞因子的表达。研究还发现了与血管生成相关的细胞因子的表达。
期刊介绍：
FBL is an international peer-reviewed open access journal of biological and medical science. FBL publishes state of the art advances in any discipline in the area of biology and medicine, including biochemistry and molecular biology, parasitology, virology, immunology, epidemiology, microbiology, entomology, botany, agronomy, as well as basic medicine, preventive medicine, bioinformatics and other related topics.
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