Chemical variability in gymnemagenin, deacyl gymnemic acid, lupeol and stigmasterol of Gymnema sylvestre R. Br. populations in India

IF 0.7 4区生物学 Q4 PLANT SCIENCES Indian Journal of Traditional Knowledge Pub Date : 2023-12-13 DOI:10.56042/ijtk.v22i4.7200

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Abstract

Variability in chemical composition of Gymnema sylvestre R.Br. (Apocynaceae) sampled from different biogeographical regions of India was investigated. The impact of geographic conditions on gymnemagenin, deacylgymnemic acid, lupeol and stigmasterol content variability was studied by using chromatographic analysis. HPLC analyses showed gymnemagenin and deacylgymnemic acid content to vary between 10.19-23.38 µg/mg and 4.70-35.42 µg/mg (w/w dry weight plant material) respectively, while lupeol and stigmasterol were found to range from 0.57 to 10.8 µg/mg and 0.25 to 15.6 µg/mg (w/w in methanolic extract) respectively, by HPTLC. Taking into account the importance of geographical origin and climatic conditions that significantly affect the production and accumulation of secondary metabolites, the selected accessions/germplasms of G. sylvestre with high concentration of biologically potential phytoconstituents could be useful to industries for harvesting optimum levels of bioactive antidiabetic agent gymnemic acids and other sterols. These elite accessions/germplasms could be promoted and used for mass propagation and cultivation to ensure sustained supply of quality raw material for herbal drug industries, companies and entrepreneurs involved in the profession of medicinal plants and as secondary source of income generation to farmers.

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印度裸冠菊（Gymnema sylvestre R. Br.）种群中裸冠菊苷、脱乙酰裸冠菊酸、羽扇豆醇和豆固醇的化学变异性

研究人员调查了从印度不同生物地理区域采样的裸冠菊（Apocynaceae）化学成分的变异性。通过色谱分析，研究了地理条件对钩藤碱、脱乙酰钩藤酸、羽扇豆醇和豆甾醇含量变化的影响。高效液相色谱分析显示，石竹素和脱乙酰基石竹酸的含量分别在 10.19-23.38 微克/毫克和 4.70-35.42 微克/毫克（重量/植物干重）之间变化，而羽扇豆醇和豆固醇的含量则分别在 0.57-10.8 微克/毫克和 0.25-15.6 微克/毫克（重量/甲醇提取物）之间变化。考虑到地理起源和气候条件对次生代谢物的产生和积累有重要影响，所选的西洋接骨木具有高浓度生物潜力的植物成分可能对工业有用，可用于收获最佳水平的生物活性抗糖尿病剂钩藤酸和其他甾醇。可以推广和利用这些精英品种/胚芽植株进行大规模繁殖和栽培，以确保为草药行业、公司和从事药用植物行业的企业家持续供应优质原料，并作为农民创收的第二来源。

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来源期刊

Indian Journal of Traditional Knowledge 生物-植物科学

CiteScore

1.80

自引率

37.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Traditional knowledge" is employed to mean knowledge, innovations and practices of indigenous and local communities embodying traditional life-styles; the wisdom developed over many generations of holistic traditional scientific utilization of the lands, natural resources, and environment. It is generally passed down by word of mouth, from generation to generation and is, for the most part, undocumented. Traditional knowledge is valid and necessary, and awaits its currently relevant wider application for human benefit. National Institute of Science Communication and Information Resources, CSIR felt a need to document the recent developments and the information bygone in this area in the form of an interdisciplinary periodical. The Indian Journal of Traditional Knowledge will carry original research papers, review articles, short communications, etc. concerned with the observation and experimental investigation of the biological activities of the materials from plants, animals and minerals, used in the traditional health-care systems such as Ayurveda, Siddha, Yoga, Unani, Naturopathy, Homoeopathy, Folk-remedies, etc. As validation of indigenous claims it will cover Ethno-biology, Ethno-medicine, Ethno-pharmacology, Ethno-pharmacognosy & Clinical Studies on efficacy .