Pregabalina preoperatoria previene las fasciculaciones y mialgias inducidas por succinilcolina: metaanálisis de ensayos aleatorizados

Abstract

Succinylcholine is the gold standard neuromuscular blocker for rapid sequence induction, however, its use is associated with fasciculations and myalgias. A systematic review and meta-analysis including randomized controlled clinical trials was performed comparing gabapentinoids versus placebo for the prevention of fasciculations and succinylcholine-induced myalgias. Six randomized clinical studies were included. The total number of patients was 481, of which 241 were in the intervention group and 240 in the placebo group. Gabapentinoids reduced the incidence of succinylcholine-induced myalgia (RR = .69; 95% CI: .56-.84; P < .001), which remained statistically significant for pregabalin (RR = .71; 95% CI: .54-.93; P = .013) and gabapentin (RR = .61; 95% CI: .45-.82; P = .001) separately. There was no difference between the groups in fasciculations (RR = .92; 95% CI: .82-1.03; P = .148). Preoperative use of gabapentinoids is associated with lower incidence of succinylcholine-induced myalgias within the first 24 hours after the procedure.