{"title":"Preparation of acid-sensitive polymeric oncology drug carriers and analysis of their efficacy","authors":"Sen Niu","doi":"10.1680/jnaen.22.00031","DOIUrl":null,"url":null,"abstract":"GA and CA4 were used as antitumor drugs to prepare TP polymers by raft, ATRP and click polymerization. GPC characterization showed that the molecular weights of cy7.5, C7A and peg in pek5k Lys azma cy7.5-c7atp polymer were 5K. The particle size of GA and CA-4 embedded in 10 mgtp and LP polymers is 3.2 mg. The toxicity of CA-4 is low, while the toxicity of GA is high. For LP and TP polymers, higher apoptosis rate will be produced under laser irradiation. The polymers are aggregated at the tumor site, which indicates that the polymer system has a better in vivo distribution effect, and the aggregation effect of TP polymer is better than that of LP polymer. The TP polymer prepared by the research has good antitumor effect and biological effect, and can be popularized and applied in the targeted treatment of tumor diseases.","PeriodicalId":44365,"journal":{"name":"Nanomaterials and Energy","volume":"248 3","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomaterials and Energy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1680/jnaen.22.00031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
GA and CA4 were used as antitumor drugs to prepare TP polymers by raft, ATRP and click polymerization. GPC characterization showed that the molecular weights of cy7.5, C7A and peg in pek5k Lys azma cy7.5-c7atp polymer were 5K. The particle size of GA and CA-4 embedded in 10 mgtp and LP polymers is 3.2 mg. The toxicity of CA-4 is low, while the toxicity of GA is high. For LP and TP polymers, higher apoptosis rate will be produced under laser irradiation. The polymers are aggregated at the tumor site, which indicates that the polymer system has a better in vivo distribution effect, and the aggregation effect of TP polymer is better than that of LP polymer. The TP polymer prepared by the research has good antitumor effect and biological effect, and can be popularized and applied in the targeted treatment of tumor diseases.
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