The Prognostic Impact of Renal Function Decline during Hospitalization for Heart Failure.

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE Kidney & blood pressure research Pub Date : 2024-01-01 Epub Date: 2023-12-23 DOI:10.1159/000535901

Otto Mayer, Jan Bruthans, Simona Bílková, Jan Filipovský

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Abstract

Introduction: We aimed to evaluate the prognostic impact of renal insufficiency and fluctuation of glomerular filtration observed during hospitalization for heart failure (HF).

Methods: We followed 3,639 patients hospitalized for acute HF and assessed the mortality risk associated with moderate or severe renal insufficiency, either permanent or transient.

Results: After adjustment, severe renal failure defined as estimated glomerular filtration (eGFR) <30 mL/min indicates ≈60% increase in 5-year mortality risk. Similar risk also had patients with only transient decline of eGFR to this range. In contrast, we did not observe any apparent mortality risk attributable to mild/moderate renal insufficiency (eGFR 30-59.9 mL/min), regardless of whether it was transient or permanent.

Conclusion: Even transient severe renal failure during hospitalization indicates poor long-term prognosis of patients with manifested HF. In contrast, only moderate renal insufficiency observed during hospitalization has no additive long-term mortality impact.

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心力衰竭住院期间肾功能下降对预后的影响。

背景：评估心力衰竭住院期间观察到的肾功能不全和肾小球滤过率波动对预后的影响评估心力衰竭（HF）住院期间观察到的肾功能不全和肾小球滤过率波动对预后的影响：我们对3636名因急性心力衰竭住院的患者进行了随访，并评估了与中度或重度肾功能不全（永久性或仅为短暂性）相关的死亡风险：经调整后，严重肾功能衰竭定义为估计肾小球滤过率（eGFR）：即使在住院期间出现短暂的严重肾功能衰竭，也预示着显性高血压患者的长期预后不佳。相比之下，住院期间观察到的中度肾功能不全不会增加长期死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.