Morphologic Heterogeneity of Carcinoma with Signet Ring Cell Features at Different Primary Sites.

IF 3.5 4区 医学 Q3 CELL BIOLOGY Pathobiology Pub Date : 2024-01-01 Epub Date: 2023-12-23 DOI:10.1159/000535941
Wissam Dahoud, Irene Gullo, Rami Imam, Laura H Tang
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Abstract

Introduction: Signet ring cells (SRCs) may be observed in carcinomas from multiple primary sites. Elucidating unknown primaries from metastases with SRCs represents a diagnostic challenge. This study examined morphologic characteristics of adenocarcinomas with SRCs from stablished primary sites and described objective features, which can aid in identifying the site of origin.

Methods: The series encompasses 257 cases of adenocarcinomas with SRCs from gastroesophageal junction (GEJ, n = 38), stomach (n = 48), pancreatobiliary system (n = 16), colorectum (n = 40), appendix (n = 32), breast (n = 41), and lung (n = 42). H&E sections were examined and scored using architectural and cytologic criteria. Morphometric analysis was performed using QuPath software.

Results: Extracellular mucin was more abundant in GEJ, colorectal, and appendiceal carcinomas. Poorly cohesive morphology was the most frequent pattern in gastric and breast carcinomas. The cytoplasmic mucin/vacuole was predominantly clear and targetoid in breast carcinomas. Breast and gastric carcinomas showed the highest nuclear to cytoplasmic (N/C) ratio, whereas appendiceal carcinoma the lowest.

Conclusion: Morphological evaluation (extracellular mucin, architectural patterns, and the nature of cytoplasmic mucin/vacuole) represents an important step to determine the cancer site of origin in adenocarcinomas with SRCs and guides further ancillary studies. Cytological morphometry may help further refine morphological criteria and facilitate the construction of digital-pathology algorithms.

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不同原发部位具有印戒细胞特征的癌的形态异质性。
导言:在多个原发部位的癌肿中都可能观察到Signet-ring-细胞(SRC)。从带有SRC的转移瘤中确定未知的原发灶是一项诊断挑战。本研究考察了来自已确定原发部位的带有SRC的腺癌的形态学特征,并描述了有助于确定原发部位的客观特征。方法:该系列包括 257 例来自胃食管交界处(GEJ,38 例)、胃(48 例)、胰胆系统(16 例)、结直肠(40 例)、阑尾(32 例)、乳腺(41 例)和肺(42 例)的带有 SRC 的腺癌。采用建筑学和细胞学标准对 H&E 切片进行检查和评分。结果显示:胃食管癌、结直肠癌和阑尾癌中细胞外粘蛋白含量较高。内聚形态差是胃癌和乳腺癌中最常见的形态。在乳腺癌中,细胞质粘蛋白/囊泡以透明和靶状为主。结论:形态学评估(细胞外粘蛋白、结构模式和细胞质粘蛋白/囊泡的性质)是确定有SRC的腺癌的原发部位并指导进一步辅助研究的重要步骤。细胞学形态测量有助于进一步完善形态学标准,并促进数字病理学算法的构建。
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来源期刊
Pathobiology
Pathobiology 医学-病理学
CiteScore
8.50
自引率
0.00%
发文量
47
审稿时长
>12 weeks
期刊介绍: ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.
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