Cell-Free Nucleic Acids for Early Prediction of Preeclampsia.

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Current Hypertension Reports Pub Date : 2024-04-01 Epub Date: 2023-12-26 DOI:10.1007/s11906-023-01291-z
Mira N Moufarrej, Virginia D Winn, Stephen R Quake
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Abstract

Purpose of review: This review summarizes the potential of cell-free nucleic acids for predicting preeclampsia, contrasts them with other methods, and discusses these findings' relevance to preeclampsia's pathogenesis and care.

Recent findings: Recent studies have demonstrated the utility of cell-free nucleic acids in early preeclampsia risk prediction. Encouragingly, nucleic acid measurement exhibits similar or better sensitivity as compared to standard screening assays and furthermore sheds light on preeclampsia's underlying placental biology. Over the past decade, liquid biopsies measuring cell-free nucleic acids have found diverse applications, including in prenatal care. Recent advances have extended their utility to predict preeclampsia, a major cause of maternal mortality. These assays assess methylation patterns in cell-free DNA (cfDNA) or gene levels in cell-free RNA (cfRNA). Currently, preeclampsia care focuses on blood pressure control, seizure prevention, and delivery. If validated, early prediction of preeclampsia through liquid biopsies can improve maternal health and deepen our understanding of its causes.

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用于子痫前期早期预测的无细胞核酸。
综述的目的:本综述总结了无细胞核酸预测子痫前期的潜力,将其与其他方法进行了对比,并讨论了这些发现与子痫前期发病机制和护理的相关性:最近的研究表明,无细胞核酸可用于早期子痫前期的风险预测。令人鼓舞的是,与标准筛查测定相比,核酸测定显示出相似或更高的灵敏度,并进一步揭示了子痫前期潜在的胎盘生物学特性。在过去的十年中,测量无细胞核酸的液体活检技术得到了广泛的应用,包括在产前护理中。最近的进展将其用途扩展到预测子痫前期,这是孕产妇死亡的一个主要原因。这些检测方法可评估无细胞 DNA(cfDNA)中的甲基化模式或无细胞 RNA(cfRNA)中的基因水平。目前,子痫前期护理的重点是控制血压、预防癫痫发作和分娩。如果得到验证,通过液体活检对子痫前期进行早期预测可以改善产妇健康,加深我们对其病因的了解。
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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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