Inside Front Cover: Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor (EXP2 6/2023)
{"title":"Inside Front Cover: Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor (EXP2 6/2023)","authors":"Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun, Wenhu Zhou","doi":"10.1002/EXP.20230602","DOIUrl":null,"url":null,"abstract":"<p>Zhou et al. have developed pH-responsive polyserotonin-modified Salmonella carrying a self-activated DNAzyme. This novel platform minimizes immune clearance, selectively disassembling in the tumor's acidic microenvironment to reactivate <i>Salmonella</i> and release DNAzyme. This “Trojan horse” strategy improves therapeutic outcomes.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230602","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20230602","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Zhou et al. have developed pH-responsive polyserotonin-modified Salmonella carrying a self-activated DNAzyme. This novel platform minimizes immune clearance, selectively disassembling in the tumor's acidic microenvironment to reactivate Salmonella and release DNAzyme. This “Trojan horse” strategy improves therapeutic outcomes.
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