Dynamic interplay of intratumoral microbiota within the colorectal cancer microenvironment

IF 9.7 4区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS VIEW Pub Date : 2023-12-29 DOI:10.1002/viw.20230100
Yuanyuan Wu, Pingping Wang, Xinyu Zhao, Ti Liu, Bo Situ, Lei Zheng
{"title":"Dynamic interplay of intratumoral microbiota within the colorectal cancer microenvironment","authors":"Yuanyuan Wu, Pingping Wang, Xinyu Zhao, Ti Liu, Bo Situ, Lei Zheng","doi":"10.1002/viw.20230100","DOIUrl":null,"url":null,"abstract":"Colorectal cancer (CRC) is a complex malignancy, influenced not only by cancer cells but also by the tumor microenvironment (TME). Within the TME, emerging evidence highlights the presence and functional roles of diverse microbial entities, referred to as intratumoral microbiota. The distribution of these microbiota exhibits significant heterogeneity and engages in dynamic interactions with tumor cells, forming a unique ecosystem. Certain bacterial strains distinctly influence the TME of CRC, affecting the characteristics and progression of the tumor. This review summarizes the intricate roles of intratumoral microbiota within CRC's TME, emphasizing their importance in the disease's development and progression, and discuss the opportunities and challenges in the field.","PeriodicalId":34127,"journal":{"name":"VIEW","volume":"17 1","pages":""},"PeriodicalIF":9.7000,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"VIEW","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/viw.20230100","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

Abstract

Colorectal cancer (CRC) is a complex malignancy, influenced not only by cancer cells but also by the tumor microenvironment (TME). Within the TME, emerging evidence highlights the presence and functional roles of diverse microbial entities, referred to as intratumoral microbiota. The distribution of these microbiota exhibits significant heterogeneity and engages in dynamic interactions with tumor cells, forming a unique ecosystem. Certain bacterial strains distinctly influence the TME of CRC, affecting the characteristics and progression of the tumor. This review summarizes the intricate roles of intratumoral microbiota within CRC's TME, emphasizing their importance in the disease's development and progression, and discuss the opportunities and challenges in the field.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
结直肠癌微环境中瘤内微生物群的动态相互作用
结直肠癌(CRC)是一种复杂的恶性肿瘤,不仅受到癌细胞的影响,还受到肿瘤微环境(TME)的影响。在肿瘤微环境中,新出现的证据强调了被称为瘤内微生物群的各种微生物实体的存在和功能作用。这些微生物群的分布具有显著的异质性,并与肿瘤细胞发生动态的相互作用,形成了一个独特的生态系统。某些细菌菌株会明显影响 CRC 的 TME,从而影响肿瘤的特征和进展。这篇综述总结了瘤内微生物群在 CRC TME 中错综复杂的作用,强调了它们在疾病发展和进程中的重要性,并讨论了该领域的机遇和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
VIEW
VIEW Multiple-
CiteScore
12.60
自引率
2.30%
发文量
0
审稿时长
10 weeks
期刊介绍: View publishes scientific articles studying novel crucial contributions in the areas of Biomaterials and General Chemistry. View features original academic papers which go through peer review by experts in the given subject area.View encourages submissions from the research community where the priority will be on the originality and the practical impact of the reported research.
期刊最新文献
Frontiers in artificial intelligence-directed light-sheet microscopy for uncovering biological phenomena and multiorgan imaging Exosomes of immune cell origin and their therapeutic potential for tumors Optical imaging for brown or beige adipose tissue Electrochemical detection of the cardiac biomarker cardiac troponin I Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1