Respiratory sinus arrhythmia in spontaneously breathing, unanesthetized newborn and adult Wistar rats

IF 1.9 4区医学 Q3 PHYSIOLOGY Respiratory Physiology & Neurobiology Pub Date : 2023-12-29 DOI:10.1016/j.resp.2023.104207

Nana Sato Hashizume, Yoichiro Kitajima, Ryoji Ide, Eishi Nakamura, Chikako Saiki

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Abstract

We examined respiratory sinus arrhythmia (RSA) and possible interaction with respiratory frequency (f_R) and heart rate (HR) in spontaneously breathing, unanesthetized newborn Wistar rats (2- to 5-day-old; n = 54) and the adult rats (8-week-old; n = 34). Instantaneous heart rate (inst-HR) was calculated as the reciprocal of the inter-beat-interval. For each breath, RSA was determined as the difference between the maximum and minimum inst-HR value. The absolute RSA or RSA% (RSA per HR) were calculated as the average RSA of 10 consecutive breaths. RSA (or RSA%) in the newborn rats was significantly lower than that in the adult rats. Correlation coefficient between RSA (or RSA%) and 1/f_R or HR/f_R, but not HR, was significant in newborn rats, whereas only that between RSA (or RSA%) and HR was significant in adult rats. The power spectrum density of heartbeat fluctuation was detectable in both age groups. The present findings suggest that RSA exists and could be influenced by f_R, rather than HR, in newborn rats.

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未经麻醉的新生大鼠和成年 Wistar 大鼠自主呼吸时的呼吸窦性心律失常

我们研究了自主呼吸、未麻醉的新生 Wistar 大鼠（2 至 5 天大；n=54）和成年大鼠（8 周大；n=34）的呼吸窦性心律失常（RSA）以及与呼吸频率（fR）和心率（HR）之间可能存在的相互作用。瞬时心率（inst-HR）按搏动间隔的倒数计算。每次呼吸的 RSA 值为 inst-HR 最大值与最小值之差。绝对 RSA 或 RSA%（每 HR 的 RSA）按连续 10 次呼吸的平均 RSA 计算。新生大鼠的 RSA（或 RSA%）明显低于成年大鼠。新生大鼠的 RSA（或 RSA%）与 1/fR 或 HR/fR 的相关系数显著，但与 HR 的相关系数不显著，而成年大鼠只有 RSA（或 RSA%）与 HR 的相关系数显著。两个年龄组的大鼠都能检测到心跳波动的功率谱密度。本研究结果表明，新生大鼠存在RSA，并且可能受fR而非HR的影响。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.