Challenges in Translating Regenerative Therapies for Spinal Cord Injury.

IF 2.4 Q1 REHABILITATION Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-11-17 DOI:10.46292/sci23-00044S
Andrew N Stewart, John C Gensel, Linda Jones, Karim Fouad
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Abstract

Regenerating the injured spinal cord is a substantial challenge with many obstacles that need to be overcome to achieve robust functional benefits. This abundance of hurdles can partly explain the limited success when applying regenerative intervention treatments in animal models and/or people. In this article, we elaborate on a few of these obstacles, starting with the applicability of animal models and how they compare to the clinical setting. We then discuss the requirement for combinatorial interventions and the associated problems in experimental design, including the addition of rehabilitative training. The article expands on differences in lesion sizes and locations between humans and common animal models, and how this difference can determine the success or failure of an intervention. An additional and frequently overlooked problem in the translation of interventions that applies beyond the field of neuroregeneration is the reporting bias and the lack of transparency in reporting findings. New data mandates are tackling this problem and will eventually result in a more balanced view of the field. Finally, we will discuss strategies to negotiate the challenging course of successful translation to facilitate successful translation of regeneration promoting interventions.

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脊髓损伤再生疗法转化过程中的挑战。
损伤脊髓的再生是一项巨大的挑战,需要克服许多障碍才能获得强大的功能性益处。在动物模型和/或人体中应用再生干预疗法的成功率有限,部分原因就在于障碍重重。在本文中,我们将从动物模型的适用性及其与临床环境的比较入手,详细阐述其中的一些障碍。然后,我们讨论了组合干预的要求和实验设计中的相关问题,包括增加康复训练。文章阐述了人类与普通动物模型在病变大小和位置上的差异,以及这种差异如何决定干预的成败。在神经再生领域之外,干预措施转化过程中还有一个经常被忽视的问题,那就是报告偏差和报告结果缺乏透明度。新的数据规定正在解决这一问题,最终将使该领域的观点更加平衡。最后,我们将讨论如何应对成功转化过程中的挑战,以促进促进再生干预措施的成功转化。
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来源期刊
CiteScore
3.20
自引率
3.40%
发文量
33
期刊介绍: Now in our 22nd year as the leading interdisciplinary journal of SCI rehabilitation techniques and care. TSCIR is peer-reviewed, practical, and features one key topic per issue. Published topics include: mobility, sexuality, genitourinary, functional assessment, skin care, psychosocial, high tetraplegia, physical activity, pediatric, FES, sci/tbi, electronic medicine, orthotics, secondary conditions, research, aging, legal issues, women & sci, pain, environmental effects, life care planning
期刊最新文献
Cerebrovascular Reactivity Following Spinal Cord Injury. Functional Sitting Balance and Anthropometric Measures Are Related to Inspiratory Muscle Performance in People with Spinal Cord Injury. Predicting Complete versus Incomplete Long-Term Functional Independence after Acute AIS Grade D Spinal Cord Injury: A Prospective Cohort Study. Management of Sleep-Disordered Breathing in a Spinal Cord Injury Rehabilitation Center: Model of Care Adaptation and Implementation Comparison of One-Year Postinjury Mobility Outcomes Between Locomotor Training and Usual Care After Motor Incomplete Spinal Cord Injury
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