Ruifang Zheng , Franklin Fuda , Jeffrey R. Gagan , Olga K. Weinberg , Prasad Koduru , Miguel Cantu , Kathleen Ludwig , Jamie M. Truscott , Robert Collins , Stephen Chung , Yazan F. Madanat , Weina Chen
{"title":"Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype","authors":"Ruifang Zheng , Franklin Fuda , Jeffrey R. Gagan , Olga K. Weinberg , Prasad Koduru , Miguel Cantu , Kathleen Ludwig , Jamie M. Truscott , Robert Collins , Stephen Chung , Yazan F. Madanat , Weina Chen","doi":"10.1016/j.lrr.2023.100410","DOIUrl":null,"url":null,"abstract":"<div><p>B/T mixed phenotype acute leukemia (MPAL) is a rare aggressive leukemia. Three cases of B/T MPAL were identified with comprehensive immunophenotypic, cytogenetic, and molecular studies. T-lineage predominant B/T MPAL shares a genetic signature with T-ALL whereas B/T lineage co-dominant B/T MPAL lacks such a T-ALL signature<em>.</em> All three patients were treated with lineage-matched-ALL therapy and alive at the last follow-up. Our study is the first to demonstrate molecular heterogeneity within B/T MPAL in a context of an immunophenotype of T-lineage versus B-lineage predominance. The implication of such a phenotype-genotype association on diagnostic classification is briefly discussed.</p></div>","PeriodicalId":38435,"journal":{"name":"Leukemia Research Reports","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221304892300050X/pdfft?md5=dc5984f2e902dbb90e8b9e1ad03a0cf8&pid=1-s2.0-S221304892300050X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Leukemia Research Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221304892300050X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
B/T mixed phenotype acute leukemia (MPAL) is a rare aggressive leukemia. Three cases of B/T MPAL were identified with comprehensive immunophenotypic, cytogenetic, and molecular studies. T-lineage predominant B/T MPAL shares a genetic signature with T-ALL whereas B/T lineage co-dominant B/T MPAL lacks such a T-ALL signature. All three patients were treated with lineage-matched-ALL therapy and alive at the last follow-up. Our study is the first to demonstrate molecular heterogeneity within B/T MPAL in a context of an immunophenotype of T-lineage versus B-lineage predominance. The implication of such a phenotype-genotype association on diagnostic classification is briefly discussed.
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