Yeon-Sook Kim, Jeoungyeon Kim, Yeon-Joo Choi, Taeuk Kang, Hye-Jin Park, Won-Jong Jang
{"title":"Molecular Typing on Human Blood Reveals the <i>Borrelia afzelii</i> Infection in Korea.","authors":"Yeon-Sook Kim, Jeoungyeon Kim, Yeon-Joo Choi, Taeuk Kang, Hye-Jin Park, Won-Jong Jang","doi":"10.3947/ic.2023.0094","DOIUrl":null,"url":null,"abstract":"<p><p>Lyme disease is a tick-borne infection in Korea. Here, clinical samples were collected from a 72-year old patient, with sudden onset of fever on April, 2018. The patient was passed away after 3rd day of doxycycline administration. The molecular diagnostic tests, nested polymerase chain reaction targeting 5S-23S rRNA intergenic spacer region (IGS) and multilocus sequence typing (MLST), showed positive for <i>Borrelia afzelii</i> from blood. Further, mutations in both 5S - 23S IGS and <i>pepX</i> allele of MLST were determined. Herein, we report the expected first death case by <i>B. afzelii</i> infection in Korea.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"55 4","pages":"500-504"},"PeriodicalIF":2.8000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10771942/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Chemotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3947/ic.2023.0094","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Lyme disease is a tick-borne infection in Korea. Here, clinical samples were collected from a 72-year old patient, with sudden onset of fever on April, 2018. The patient was passed away after 3rd day of doxycycline administration. The molecular diagnostic tests, nested polymerase chain reaction targeting 5S-23S rRNA intergenic spacer region (IGS) and multilocus sequence typing (MLST), showed positive for Borrelia afzelii from blood. Further, mutations in both 5S - 23S IGS and pepX allele of MLST were determined. Herein, we report the expected first death case by B. afzelii infection in Korea.
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