Association Between Paclitaxel and Stroke: Mendelian Randomization

Bingwu Chen, Xian Zhou, Tao Yang, Mei-xia Xu, Tao Liu, Zhong Dai, Chuanhua Bi, Tao Xu
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Abstract

Paclitaxel, a naturally derived anticancer drug extracted from the plant Taxus brevifolia, holds significant medicinal and clinical value. Recently, more and more studies have shown that paclitaxel may be involved in the risk of stroke. However, there is still controversy over the relationship between the two at present. The objective of this study is to investigate a causality between paclitaxel and stroke using a two-sample Mendelian randomization (MR). Summary statistics for paclitaxel and stroke were derived from multiple comprehensive genome-wide association studies. The Inverse-variance weighting (IVW) method was used for preliminary analysis. Additionally, MR Steiger was employed to evaluate the robustness of these genetic variants in relation to paclitaxel and stroke. This study did not find a correlation between paclitaxel and stroke (OR: 1.008; 95% CI: 0.894–1.013, P = 0.270). This relationship was supported by other analysis methods as well. Furthermore, MR Steiger’s analysis confirmed a causal relationship between paclitaxel and stroke ( “TRUE”). Our research has shown that paclitaxel does not lead to stroke, and further exploration of the relationship between the two is still needed.
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紫杉醇与中风的关系:孟德尔随机化
紫杉醇是从植物紫杉(Taxus brevifolia)中提取的天然抗癌药物,具有重要的药用和临床价值。最近,越来越多的研究表明,紫杉醇可能与中风风险有关。然而,目前对两者之间的关系仍存在争议。本研究的目的是采用双样本孟德尔随机法(MR)研究紫杉醇与中风之间的因果关系。紫杉醇与中风的汇总统计数据来自多项综合性全基因组关联研究。初步分析采用了逆方差加权法(IVW)。此外,还采用了 MR Steiger 来评估这些基因变异与紫杉醇和中风关系的稳健性。该研究未发现紫杉醇与中风之间存在相关性(OR:1.008;95% CI:0.894-1.013,P = 0.270)。其他分析方法也支持这种关系。此外,MR Steiger 的分析证实了紫杉醇与中风之间的因果关系("TRUE")。我们的研究表明,紫杉醇不会导致中风,因此仍需进一步探讨两者之间的关系。
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来源期刊
Journal of Biobased Materials and Bioenergy
Journal of Biobased Materials and Bioenergy 工程技术-材料科学:生物材料
自引率
0.00%
发文量
60
审稿时长
6 months
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