{"title":"A Case of Extremely Premature Baby with Persistent Metabolic Acidosis, Hypoglycemia and Dyselectrolytemia Induced by Liposomal Amphotericin B","authors":"Ji Won Koh","doi":"10.15746/sms.23.016","DOIUrl":null,"url":null,"abstract":"Amphotericin B is widely used in the treatment of neonatal invasive fungal disease. Liposomal amphotericin B (LAmB) is now preferred over conventional amphotericin B deoxycholate due to its lower kidney toxicity. However, it is essential to monitor the possible side effects of LAmB when treating extremely premature infants. Herein, we present a case of an extremely premature infant who exhibited persistent metabolic acidosis, hypoglycemia, and dyselectrolytemia after administration of LAmB for a suspected fungal infection.","PeriodicalId":22016,"journal":{"name":"Soonchunhyang Medical Science","volume":" 95","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Soonchunhyang Medical Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15746/sms.23.016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Amphotericin B is widely used in the treatment of neonatal invasive fungal disease. Liposomal amphotericin B (LAmB) is now preferred over conventional amphotericin B deoxycholate due to its lower kidney toxicity. However, it is essential to monitor the possible side effects of LAmB when treating extremely premature infants. Herein, we present a case of an extremely premature infant who exhibited persistent metabolic acidosis, hypoglycemia, and dyselectrolytemia after administration of LAmB for a suspected fungal infection.
两性霉素 B 广泛用于治疗新生儿侵袭性真菌病。由于脂质体两性霉素 B（LAmB）对肾脏的毒性较低，因此现在比传统的脱氧胆酸两性霉素 B 更受青睐。然而，在治疗极早产儿时，必须监测 LAmB 可能产生的副作用。在此，我们介绍了一例极早产儿病例，该患儿在服用 LAmB 治疗疑似真菌感染后出现了持续性代谢性酸中毒、低血糖和失代偿血症。
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