SYNTHESIS, CHARACTERIZATION AND BILOGICAL EVALUATION OF 2,4,6- TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES

Abstract

A new series of 2,4,6-trisubstituted 1,3,5-triazine derivatives were synthesized from 2,4,6-trichloro-1,3,5-triazine(Cyanuric Chloride) and 4-(4-aminophenyl)morpholin-3-one via regioselective reaction followed by reflux with substituted aryl amine in the presence of catalytic amount of triethyl amine. All the synthesized compounds were characterized by IR, 1HNMR, Mass and Elemental Analysis. The newly synthesized compounds were also screened for their in vitro antimicrobial activity against standard drugs and some of them found to be remarkably active.