Melaleuca cajuputi Powell Essential Oil: A Review of Botanical, Phytochemical and Pharmacological Properties

Abstract

Melaleuca cajuputi Powell essential oil (MCEO) is widely used in Malay traditional medicine for the treatment of stomach cramps, cough, acne, insect bites, thrush problems and many more. The demand for medicinal applications of MCEO is gradually increasing among the Southeast Asian community. All information regarding MCEO was collected via internet sources such as Google Scholar, Elsevier, PubMed, Baidu Scholar, Web of Science and local books. Meta-analysis method was performed to identify all publications or relevant books regarding the MCEO range from 1998 to 2021. The main bioactive compounds of MCEO include terpenes, esters, aldehydes and alkenes. Scientific research on MCEO has revealed a wide range of pharmacological activities such as contact and fumigant toxicity, repellence, antibacterial activity and many more. The MCEO has a huge potential for pharmaceutical and nutraceutical applications, but comprehensive toxicity studies must be conducted to ensure their safety. Research on pharmacokinetics studies and potential drug interactions with standard-of-care medications is still limited, which calls for additional studies, particularly in humans. Further assessments and clinical trials should be performed before it can be integrated into medicinal practices.