Evaluation of phosphatase and tensin homologue (PTEN) expression in gastric cancer and its relationship with histopathological findings

Q4 Medicine Revista Espanola de Patologia Pub Date : 2024-01-01 DOI:10.1016/j.patol.2023.11.001

Seyed Amir Miratashi Yazdi , Fatemeh Hoseini , Arezoo Eftekhar Javadi , Elham Nazar

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Abstract

Introduction

Phosphatase and tensin homologue (PTEN) is an important tumour suppressor in multi-step tumorigenesis. To establish the role of PTEN in gastric cancer progression, we examined the PTEN expression degree in gastric cancer tissues. We also explained the connection between PTEN expression and histopathological findings.

Materials and methods

Our study was cross-sectional and made up of 50 patients with known gastric cancer. Immunohistochemical staining for PTEN was done on gastric cancer tissues. Tumour behaviour was estimated by histopathological assessments.

Results

Twenty-seven (54%) of the 50 patients had PTEN staining. The evaluation of the connection between PTEN expression and demographic data and tumour behaviours revealed no meaningful relationship between PTEN expression and patients’ age, gender, tumour site and size, tumour type, tumour grade and stage, neural, and lymphovascular invasion (P-value > 0.05).

Conclusion

PTEN expression level is expected to be a significant molecular event in the progression of gastric cancer and may be a predictive marker for gastric cancer behaviours dependent on society.

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评估胃癌中磷酸酶和天丝同源物 (PTEN) 的表达及其与组织病理学结果的关系

引言磷脂酶和天丝同源物（PTEN）是多阶段肿瘤发生过程中的重要肿瘤抑制因子。为了确定 PTEN 在胃癌进展中的作用，我们研究了 PTEN 在胃癌组织中的表达水平，并解释了 PTEN 表达与组织病理学结果之间的联系。材料和方法我们的研究是横断面研究，由 50 名已知的胃癌患者组成。对胃癌组织进行了 PTEN 免疫组化染色。结果50名患者中有27人（54%）有PTEN染色。对 PTEN 表达与人口统计学数据和肿瘤行为之间关系的评估显示，PTEN 表达与患者的年龄、性别、肿瘤部位和大小、肿瘤类型、肿瘤分级和分期、神经和淋巴管侵犯之间没有有意义的关系（P 值为 0.05）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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