Neurotropic effect of new coumarin derivatives on the impulsive and compulsive components of gambling addiction in rats.

Abstract

The search for new neuroactive compounds that have a selective effect on the mechanisms of emotional reinforcement in gambling addiction is of interest. There have been no previous studies on the effects of coumarins on gambling addiction. Aim. The aim of our work was to study the effect of new coumarin derivatives on the impulsive and compulsive components of gambling addiction in rats. Materials and methods. The effects of drugs on elements of gambling addiction were assessed in rats in the marble burying test and probability and magnitude of reinforcement in the three-arm maze, a version of the IOWA test. The effect of 6 coumarin derivatives was studied - LVM-091, LVM-092, LVM-096, LVM-099, LVM-S144, IEM-2886 Results and its discussion. In the burrowing balls test, substances synthesized on the basis of coumarin LVM-092, LVM-099, LVM-S144, IEM-2886 reduced the level of compulsivity, reducing the number of buried balls compared to the control group and the diazepam group (p0.05). In the probability and magnitude of reinforcement test, after the administration of drugs LVM-091, LVM-099 LVM-S144 and IEM-2886, the level of impulsivity and risk behavior decreased, reducing the number of animals entering the sleeve with the greatest reinforcement and its low probability. Conclusion. New coumarin derivatives cause an anticompulsive effect and reduce the level of impulsivity in rats, which in the future can be used in the treatment of obsessive-compulsive disorders and addictive conditions, such as Internet addiction and gaming addiction.