ANTICALCIURIA EFFECT OF METHANOLIC ROOT EXTRACT OF LAGERSTROEMIA SPECIOSA (L). PERS (LYTHRACEAE) AGAINST HIGH PROTEIN DIET INGESTED IN ALBINO RATS

Abstract

Nephrolithiasis, commonly known as kidney stone disease or urolithiasis, is a crystallopathy in which a solid mass forms in the urinary tract. The aim of the present research is to evaluate the way that albino rats administered with a high-protein diet, react to methanolic root extracts of Lagerstroemia speciosa anticalciuric properties. Medicinal plants are frequently utilised in folk medicine to treat a wide range of illnesses. Banaba is the common name for L. speciosa, a member of the Lythraceae family; Poomaruthu is its Tamil name. The test animals were given a diet high in protein and low in protein as well as 45 days of treatment with methanolic root extracts of L. speciosa. The experiment was scheduled with a sample collection, biochemical inquiries, and histopathological exams. The experiment had been scheduled with a sample collection, biochemical investigations, and histopathological evaluations. The biochemical data reveal that as compared to the control, III, and V groups, the low-protein diet groups II and IV had greater blood urea concentrations. The low-protein diet groups II and IV exhibited an increased blood creatinine concentration in contrast to the control, III, and V groups, while group V (H.P+MRE 500 mg/kg) demonstrated a nearly identical outcome to that of the control groups. L. speciosa root extracts in methanol are given to groups to control creatinine concentration. The normal control group's histopathological analysis revealed tubules with a single epithelial lining along the outermost layer that were normal in size.