Sajad Najafi, Farhoodeh Ghaedrahmati, Mahrokh Abouali Gale Dari, Maryam Farzaneh, R. Mohammad Jafari
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引用次数: 0
Abstract
Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease influenced by various genetic, epigenetic, and environmental factors. While treatment options such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains poor due to high rates of distant and lymphatic metastasis. Recent research has shed light on the role of non-coding RNAs (ncRNAs) in cervical cancer development, with circular RNAs (circRNAs) emerging as a potentially significant regulator of cellular processes. Through targeting miRNAs/mRNAs, circRNAs can impact cell growth and invasion in cervical cancer cells, making them a promising biomarker for diagnosis and treatment. This review provides an overview of the functional roles of circRNAs in the context of cervical cancer.
期刊介绍：
In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders.
The journal publishes timely in-depth reviews, research article and drug clinical trial studies in the field of signal transduction therapy. Thematic issues are also published to cover selected areas of signal transduction therapy. Coverage of the field includes genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases. Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.
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