The Role of Catecholamines (Epinephrine/Norepinephrine) and Beta Blocker in Head and Neck Cancer

Abstract

Beta blockers are used for various indications, particularly cardiac arrhythmias, cardioprotection after myocardial infarction, hypertension, migraine, tremor, and anxiety disorders, by inhibiting the sympathetic actions of catecholamine hormones (i.e., epinephrine and norepinephrine). This sympathetic mechanism occurs via beta-adrenergic receptors. Recently, experimental evidence showed that malignant cell lines express beta-adrenergic receptors and that sympathomimetic neurotransmitters may affect carcinogenesis through these receptors. These neurotransmitters are suggested to have a major impact on secondary tumor growth and to contribute to metastasis, induction of angiogenesis, and tissue invasion. Given that beta-blockers are considered safe, cheap, and effective, the potential beneficial effects of their use for cancer would be of interest. However, evidence from epidemiological and clinical studies has been inconclusive. Especially the effect of beta-blockers on head and neck cancer has rarely been investigated.