Clinical Course and Therapy Methods of Aquagenic Urticaria

O. M. Kudelina, E. Gantsgorn, Yu. S. Maklyakov, D. L. Tkachenko, L. A. Avakyan, P. A. Chubyreva, Y. G. Amirova, Yu. A. Karpova, A. N. Dulskaya, I. B. Meshi
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Abstract

Aquagenic urticaria is one of the rarest forms of allergic reaction in the body. Aquagenic urticaria is clinically manifested by itching and urticarial rashes 5–10 min after contact with water. The signs disappear within 30–60 min. The standard therapy regimen includes the administration of second-generation H1-histamine receptor blockers and barrier creams with ceramides. In recent years, the use of monoclonal antibody therapy (omalizumab) has been considered in cases where antihistamines are ineffective.
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水源性荨麻疹的临床过程和治疗方法
水源性荨麻疹是人体最罕见的过敏反应之一。水源性荨麻疹的临床表现为接触水后 5-10 分钟出现瘙痒和荨麻疹。症状在 30-60 分钟内消失。标准治疗方案包括使用第二代 H1 组胺受体阻断剂和含神经酰胺的隔离霜。近年来,在抗组胺药无效的情况下,也考虑使用单克隆抗体疗法(奥马珠单抗)。
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