H D Flad, H Loppnow, W Feist, M H Wang, H Brade, S Kusumoto, E T Rietschel, A J Ulmer
{"title":"Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide partial structures.","authors":"H D Flad, H Loppnow, W Feist, M H Wang, H Brade, S Kusumoto, E T Rietschel, A J Ulmer","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Minimal concentration ranges of lipopolysaccharides, natural and synthetic lipid As, and partial structures were established for the induction of release of IL-1 and TNF from human MNC. LPS was more potent than lipid A. Partial structures of lipid A lacking nonhydroxylated fatty acids were inactive, but in combination with LPS or lipid A exhibited time-dependent synergistic or antagonistic effects.</p>","PeriodicalId":18130,"journal":{"name":"Lymphokine research","volume":"8 3","pages":"235-8"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lymphokine research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Minimal concentration ranges of lipopolysaccharides, natural and synthetic lipid As, and partial structures were established for the induction of release of IL-1 and TNF from human MNC. LPS was more potent than lipid A. Partial structures of lipid A lacking nonhydroxylated fatty acids were inactive, but in combination with LPS or lipid A exhibited time-dependent synergistic or antagonistic effects.
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