Orally Disintegrating Film: A Review of Its Formulation and Manufacturing Method

K. Liew, Ganesan Gobal, Hanifah Mohd Rofiq, Hiu Ching Phang, Siew-Keah Lee, Long Chiau Ming, A. H. Uddin, Yik-Ling Chew, Vijayakumar Lakshminarayanan
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Abstract

Oral route drug delivery system is still considered as the most convenient and patient friendly drug delivery route. Over the decades, many research has been performed to improve the functionality oral dosage form. Orally disintegrating film (ODF) is a newer oral drug delivery system, which is in the form of a thin film that will disintegrate in the oral cavity within a matter of seconds. The aim of this review paper is to recap ODF, its benefits, formulation contents and manufacturing method. With more research and development work has been conducted on ODF, the dosage form is expected to be manufactured and scaled up to be commercializable products to be sold in the market.
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口腔崩解膜:配方与制造方法综述
口服给药系统仍然被认为是最方便、对病人最友好的给药途径。几十年来,人们为改进口服剂型的功能进行了大量研究。口腔崩解膜(ODF)是一种较新的口服给药系统,它呈薄膜状,在口腔中几秒钟内就会崩解。本综述旨在概述口腔崩解膜及其优点、配方内容和制造方法。随着对 ODF 开展更多的研究和开发工作,预计这种剂型的生产和规模将扩大到可在市场上销售的商业化产品。
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