Timolol Maleate In Situ Ophthalmic Mucoadhesive-Thermosensitive Gel: Development and Characterization

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-09-19 DOI:10.4274/tjps.galenos.2023.50723
Sibel İLBASMIŞ TAMER, Özlem Çulcu, Eda Turan, Fahriye Figen Tirnaksiz
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Abstract

Objectives: The purpose of this study was to prepare a sustained delivery mucoadhesive-thermosensitive formulation containing poloxamer 338 (P338), poloxamer 188 (P188) and mucoadhesive agents such as chitosan (CHT) and carboxymethylcellulose (CMC) to increase the ophthalmic bioavailability of Timolol Maleate (TM). Materials and Methods: Gels were prepared by mixing different amounts of P338, P188 and mucoadhesive agents in cold isotonic water with a magnetic stirrer. The sol-gel gelation time of the gels was determined using the test tube inversion method. Viscosity measurements and analysis of mechanical properties of gel formulations were carried out. In vitro release using dialysis membrane and ex vivo permeation studies using fresh cow eyes were performed.
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马来酸噻吗洛尔原位眼用粘胶-热敏凝胶:开发与表征
研究目的本研究的目的是制备一种持续给药的粘附热敏制剂,该制剂含有 poloxamer 338 (P338)、poloxamer 188 (P188)以及壳聚糖 (CHT) 和羧甲基纤维素 (CMC) 等粘附剂,以提高马来酸噻吗洛尔 (TM) 的眼用生物利用度。材料和方法:在磁力搅拌器的作用下,将不同量的 P338、P188 和粘合剂在冷等渗水中混合,制备凝胶。采用试管倒置法测定凝胶的溶胶-凝胶凝胶化时间。对凝胶配方进行了粘度测量和机械性能分析。使用透析膜进行了体外释放研究,并使用新鲜牛眼进行了体内外渗透研究。
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CiteScore
3.60
自引率
5.90%
发文量
79
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