NEUROPLASTICITY IN CEREBRAL VISUAL IMPAIRMENT

Abstract

Introduction. The field of pediatric stroke has developed rapidly and has reached the stage where focused funding prioritization is required to make further advances including understanding mechanisms and optimal treatments. The existence of highly motivated and collaborative researchers in this field provides tremendous potential for leveraging research productivity. In recent years, research has been expanding in the direction of studying central hemodynamics, general and local intracerebral circulation, as well as orbital and intraocular hemodynamics when studying the dynamics of cerebral visual impairment (CVI) in children with pre- and perinatal encephalopathy. The aim of the study was studying the mechanisms of the relationship between neuroplasticity and cerebral visual impairment at the recovery stages of intracranial hemodynamic and liquor dynamic disturbances in children with NE. Materials and methods. Over the past 10 years, out of 3,500 children aged from 3 months to 6 years examined by us, with the help and cooperation of the children's neurological hospital, the Republican Perinatal Center and the Research Institute of Pediatrics, 1,500 children were diagnosed with acute cerebrovascular accident in the neonatal period of life. Homeostasis indicators-catecholamines in the blood, excretion in the urine, the sugar and cortisol in the blood, electrolytes in plasma and erythrocytes. NSG, MRI, CDU. The reactivity of BP, of the pulse and respiration to vegetotropic drugs and PA.EEG (sleep rhythm, emotional and motor activity) Results. It has been proven that the decisive mechanisms of recovery options depend on the orientation of the hypothalamic-pituitary relationship and the nature of homeostatic aberrations. The overwhelming majority of these children have experienced catecholamine excite dumping syndrome over these long years and had a clinical picture of both cerebral pathology and CVI. By compiling histograms, it was possible to establish that the effect of cholinergic mechanisms on general hemodynamics was less pronounced than on intraorbital blood circulation. In other words, the assessment of hemodynamic responsiveness to the stimulus revealed a more significant fluctuation in the index of intracranial rather than general hemodynamics. Conclusion. Analysis of variance proves that the stability of the mean dynamic blood pressure is one of the leading mechanisms for stabilization of adaptive homeostatic neuroplasticity of the CNS and visual analyzer.