Muzammil Muzaffar, Arifa Hassan Sheikh, Mohd Rafi Reshi
{"title":"Effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats","authors":"Muzammil Muzaffar, Arifa Hassan Sheikh, Mohd Rafi Reshi","doi":"10.22270/ajprd.v11i3.1230","DOIUrl":null,"url":null,"abstract":"Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutical Research and Development","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22270/ajprd.v11i3.1230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.
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