[Histologic changes of the endometrium after Danazol treatment].

Abstract

Authors have applied Danazol-treatment to 15 sexually mature patients because of beningn, menorrhagic bleeding disturbances. Three months after daily 400 to 600 mg Danazol an amenorrhea ensued. Steroid determinations during drug administration were complemented by endometrial biopsy in the amenorrheal state. Samples were studied light and electron microscopically. Upon Danazol-treatment the endometrium showed a patterns resembling that in atrophy or in early proliferations stage of the menstrual cycle. This corresponded to estrogen values obtained. In 3 out of 15 cases the pseudosecretory transformation of the endometrium was observed which is explained by the interaction between Danazol and progesterone receptors.