The Role of Curcumin in Gastric Carcinoma by Modulating the Immune System and its SAR

Q4 Pharmacology, Toxicology and Pharmaceutics Journal of Natural Remedies Pub Date : 2024-01-01 DOI:10.18311/jnr/2024/34910

Akshay Kumar, C. Majee, R. Mazumder, Ruchi Sharma, Avijit Mazumder, Rashmi Mishra, Pankaj Wadhwa

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Abstract

The second most prevalent cancer in the world and the fifth most common malignant tumour is gastric carcinoma. It is thought that several factors, including genetics, epigenetics, and environmental impacts, contribute to the development of gastric cancer. One of the main pathogenic variables associated with stomach cancer risk has been identified as inflammation. There are currently few methods to treat the gastric carcinoma. Therefore, an alternative plan is urgently needed. Explaining the importance of curcumin derived from Curcuma longa Linn. in stomach cancer is the goal of this review. According to recent research, Curcumin (CUR) has a great effect against stomach mucosal injury brought on by non-steroidal anti-inflammatory medicines, gastric mucosal injury in rats, stress haemorrhage, and Helicobacter pylori infection. In this review article, we have discussed the chemistry of CUR, the role of CUR in immunomodulation, and gastric cancer. We have also highlighted the various signalling pathway of gastric cancer where CUR work. By controlling miRNAs on gastric cancer and other relevant signal pathways, CUR exhibits notable anti-inflammatory and anti-cancer properties. In future there are more research work will be done on CUR.

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姜黄素通过调节免疫系统及其 SAR 在胃癌中的作用

胃癌是世界上发病率第二高的癌症，也是第五大最常见的恶性肿瘤。据认为，包括遗传学、表观遗传学和环境影响在内的多种因素导致了胃癌的发生。与胃癌风险相关的主要致病变量之一已被确定为炎症。目前，治疗胃癌的方法很少。因此，迫切需要一种替代方案。本综述旨在解释姜黄素对胃癌的重要性。根据最近的研究，姜黄素（CUR）对非甾体抗炎药物引起的胃黏膜损伤、大鼠胃黏膜损伤、应激性出血和幽门螺旋杆菌感染有很好的疗效。在这篇综述文章中，我们讨论了 CUR 的化学性质、CUR 在免疫调节和胃癌中的作用。我们还强调了 CUR 在胃癌中发挥作用的各种信号通路。通过控制胃癌和其他相关信号通路的 miRNA，CUR 具有显著的抗炎和抗癌特性。今后，我们还将开展更多有关 CUR 的研究工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Remedies Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

0.40

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0.00%

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期刊介绍： Nature can provide all the remedies, for all. All substances produced by nature can be recognized; all cells talk the same language as we all are from the same mother cell. Journal of Natural Remedies is devoted toward the understandings of all remedies from nature. Journal of Natural Remedies publishes original articles related to utilisation of any natural source for remedy including bioactive natural products. Studies related to the resources, chemistry (including analytical), biological activity, biotechnology and pharmacology (including toxicology) of archaea, bacteria, protistas, fungi, plants, animals, viruses and minerals fall within the journal’s scope.