TOPLESS Corepressors as an Emerging Hub of Plant Pathogen Effectors.

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Plant-microbe Interactions Pub Date : 2024-03-01 Epub Date: 2024-03-27 DOI:10.1094/MPMI-10-23-0158-FI

Mamoona Khan, Armin Djamei

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Abstract

Transcriptional corepressors form an ancient and essential layer of gene expression control in eukaryotes. TOPLESS and TOPLESS-RELATED (TPL/TPR) proteins constitute a conserved family of Groucho (Gro)/thymidine uptake 1 (Tup1)-type transcriptional corepressors and control diverse growth, developmental, and stress signaling responses in plants. Because of their central and versatile regulatory roles, they act as a signaling hub to integrate various input signaling pathways in the transcriptional responses. Recently, increasing pieces of evidence indicate the roles of TPL/TPR family proteins in the modulation of plant immunity. This is supported by studies on effectors of distantly related pathogens that target TPL/TPR proteins in planta. In this short review, we will summarize the latest findings concerning pathogens targeting plant TPL/TPR proteins to manipulate plant signaling responses for the successful invasion of their hosts. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.

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无顶核心抑制因子是植物病原体效应因子的新兴枢纽。

转录核心抑制因子是真核生物基因表达控制的一个古老而重要的层次。TOPLESS和TOPLESS-RELATED（TPL）/TPR）蛋白构成了一个保守的Groucho（Gro）/胸苷摄取1（Tup1）型转录核心抑制因子家族，控制着植物的各种生长、发育和胁迫信号反应。由于它们的核心和多功能调控作用，它们在转录反应中充当了整合各种输入信号途径的信号枢纽。最近，越来越多的证据表明 TPL/TPR 家族蛋白在植物免疫调节中的作用。对植物体内以 TPL/TPR 蛋白为靶标的远缘病原体效应物的研究支持了这一观点。在这篇简短的综述中，我们将总结病原体以植物 TPL/TPR 蛋白为目标操纵植物信号反应以成功入侵宿主的最新发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Plant-microbe Interactions 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

250

审稿时长

3 months

期刊介绍： Molecular Plant-Microbe Interactions® (MPMI) publishes fundamental and advanced applied research on the genetics, genomics, molecular biology, biochemistry, and biophysics of pathological, symbiotic, and associative interactions of microbes, insects, nematodes, or parasitic plants with plants.