Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed.

IF 8.1 1区 医学 Infectious Diseases of Poverty Pub Date : 2024-01-12 DOI:10.1186/s40249-024-01174-8
Robert Colebunders, Joseph Nelson Siewe Fodjo, Olivia Kamoen, Luís-Jorge Amaral, Amber Hadermann, Chiara Trevisan, Mark J Taylor, Julia Gauglitz, Achim Hoerauf, Yasuaki Sato, Katja Polman, María-Gloria Basáñez, Dan Bhwana, Thomson Lakwo, Gasim Abd-Elfarag, Sébastien D Pion
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Abstract

Background: There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health problem.

Main text: During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with epilepsy.

Conclusions: To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

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盘尾丝虫病流行地区迫切需要治疗和预防癫痫。
背景:越来越多的流行病学证据支持盘尾丝虫病与癫痫发作之间的关联,从而强化了盘尾丝虫病相关癫痫(OAE)的概念。本文旨在提供有关 OAE 的最新知识,并就如何解决这一公共卫生问题向世界卫生组织提出建议:在 2023 年 9 月 19-21 日于比利时安特卫普举行的第二届 OAE 国际研讨会上,与会者认识到 OAE 是一个严重但被忽视的公共卫生问题,尤其是在盘尾丝虫病仍然高发的撒哈拉以南非洲地区。来自前瞻性人群研究的证据表明,加强消除盘尾丝虫病的工作可显著降低 OAE 发病率。有必要验证 OAE 病例定义,以估算疾病负担,并确定需要加强消除盘尾丝虫病计划和整合癫痫护理的盘尾丝虫病流行地区。预计提高人们对 OAE 的认识将促进伊维菌素的普及。实施社区癫痫治疗计划,免费提供抗癫痫药物(ASMs),在减少癫痫发作频率和改善癫痫患者整体生活质量方面显示出很高的有效性:为减轻 OAE 负担,需要在社区、国家和国际层面加强盘尾丝虫病和精神健康计划之间的合作。需要做出紧急努力,确保在盘尾丝虫病流行地区不间断地提供免费的 ASM。此外,应将 OAE 纳入盘尾丝虫病疾病负担的量化中。
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来源期刊
Infectious Diseases of Poverty
Infectious Diseases of Poverty INFECTIOUS DISEASES-
自引率
1.20%
发文量
368
期刊介绍: Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.
期刊最新文献
Role of social innovations in health in the prevention and control of infectious diseases: a scoping review. Approaching onchocerciasis elimination in Equatorial Guinea: Near zero transmission and public health implication. Global burden associated with rare infectious diseases of poverty in 2021: findings from the Global Burden of Disease Study 2021. One-year impact of behavioural interventions on schistosomiasis-related knowledge, attitude and practices of primary schoolchildren in Pemba, Tanzania. Establishing a dominant early larval sex-selection strain in the Asian malaria vector Anopheles stephensi.
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