Constructed competitive endogenous RNA network and patterns of immune infiltration revealing the prognostic signature for cervical cancer.

IF 3 4区 医学 Q2 GENETICS & HEREDITY Epigenomics Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI:10.2217/epi-2023-0336
Luqiao Luo, Fei Qiao, Ke Zhou, Qiang Tu, Jiao He, Haoqi Huang, Chao Liu, Huihua Cai
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Abstract

Aim: To investigate the relationship between potential abnormal epigenetic modification and immune cell infiltration in patients with cervical carcinoma. Materials & methods: RNA expression profiles from The Cancer Genome Atlas database were used to explore the relationship between key biomarkers and tumor-infiltrating immune cells and for clinical specimen validation. Results: Two nomogram models were developed, one with specific ceRNA and the other based on biological markers of related tumor-infiltrating immune cells. Moreover, a key biomarker (RIPOR2), which was significantly relevant to CD8 T cells. Conclusion: RIPOR2 and CD8 T cells play a crucial role in the development and progression of cervical carcinoma, suggesting their potential as markers for guiding future therapeutic strategies.

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构建竞争性内源性 RNA 网络和免疫浸润模式,揭示宫颈癌的预后特征。
目的:研究宫颈癌患者潜在异常表观遗传修饰与免疫细胞浸润之间的关系。材料与方法:利用癌症基因组图谱数据库中的 RNA 表达谱,探讨关键生物标志物与肿瘤浸润免疫细胞之间的关系,并进行临床标本验证。结果:建立了两个提名图模型,一个是特定的 ceRNA,另一个是基于相关肿瘤浸润免疫细胞的生物标志物。此外,一个关键的生物标记物(RIPOR2)与 CD8 T 细胞显著相关。结论RIPOR2和CD8 T细胞在宫颈癌的发生和发展过程中起着至关重要的作用,这表明它们有可能成为指导未来治疗策略的标志物。
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来源期刊
Epigenomics
Epigenomics GENETICS & HEREDITY-
CiteScore
5.80
自引率
2.60%
发文量
95
审稿时长
>12 weeks
期刊介绍: Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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