Mixed Adeno-Neuroendocrine Neoplasms: Two Cases, One Institution.

CRSLS : MIS case reports from SLS Pub Date : 2023-01-15 eCollection Date: 2023-10-01 DOI:10.4293/CRSLS.2023.00045

Casey Paterson, Gabrielle Perrotti, Bakhtawar Mushtaq, Jaclyn Heilman, Steven Fassler

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Abstract

Epithelial tumors with neuroendocrine and nonendocrine components constitute the rare yet aggressive entity of neoplasms of the gastro-entero-pancreatic tract. These tumors were first named "mixed adeno-neuroendocrine carcinomas" (MANECs) by the World Health Organization in 2010 and in 2017 renamed "mixed neuroendocrine non-neuroendocrine neoplasms" (MiNENs). Combined adenocarcinoma and neuroendocrine carcinoma neoplasms are a rare occurrence within the gastrointestinal tract. In this report, we describe two separate cases of mixed rectal adeno-neuroendocrine carcinomas and their treatment. We describe two cases at one institution of mixed neuroendocrine non-neuroendocrine rectal neoplasms. Given the rarity of diagnosis and inconsistencies in both nomenclature and treatment recommendations in the literature, mixed adeno-neuroendocrine carcinoma epidemiology and prognosis are not yet fully understood. Future prospective trials with a focus in management of MiNENs will offer valuable insight into these rare mixed carcinomas.

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混合性腺神经内分泌肿瘤：一个机构，两个病例。

具有神经内分泌和非内分泌成分的上皮性肿瘤构成了胃-肠-胰腺道肿瘤中罕见但具有侵袭性的实体。世界卫生组织于 2010 年首次将这些肿瘤命名为 "混合腺癌-神经内分泌癌"（MANECs），并于 2017 年更名为 "混合神经内分泌-非神经内分泌肿瘤"（MiNENs）。腺癌和神经内分泌癌的合并肿瘤在胃肠道中较为罕见。在本报告中，我们分别描述了两例直肠腺癌-神经内分泌癌混合瘤病例及其治疗方法。我们描述了一家医疗机构的两例神经内分泌与非神经内分泌混合型直肠肿瘤。鉴于诊断的罕见性以及文献中命名和治疗建议的不一致性，混合型腺神经内分泌癌的流行病学和预后尚未完全明了。未来以治疗混合腺内分泌癌为重点的前瞻性试验将为了解这些罕见的混合腺内分泌癌提供有价值的信息。

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CRSLS : MIS case reports from SLS

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