Peroxisomal hydrogen peroxide signaling: A new chapter in intracellular communication research

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Opinion in Chemical Biology Pub Date : 2024-01-17 DOI:10.1016/j.cbpa.2024.102426
Marc Fransen, Celien Lismont
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Abstract

Hydrogen peroxide (H2O2), a natural metabolite commonly found in aerobic organisms, plays a crucial role in numerous cellular signaling processes. One of the key organelles involved in the cell's metabolism of H2O2 is the peroxisome. In this review, we first provide a concise overview of the current understanding of H2O2 as a molecular messenger in thiol redox signaling, along with the role of peroxisomes as guardians and modulators of cellular H2O2 balance. Next, we direct our focus toward the recently identified primary protein targets of H2O2 originating from peroxisomes, emphasizing their importance in unraveling the complex interplay between peroxisomal H2O2 and cell signaling. We specifically focus on three areas: signaling through peroxiredoxin redox relay complexes, calcium signaling, and phospho-signaling. Finally, we highlight key research directions that warrant further investigation to enhance our comprehension of the molecular and biochemical mechanisms linking alterations in peroxisomal H2O2 metabolism with disease.

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过氧化氢信号:细胞内通讯研究的新篇章
过氧化氢(H2O2)是有氧生物体中常见的一种天然代谢物,在许多细胞信号传递过程中发挥着至关重要的作用。过氧物酶体是参与细胞 H2O2 代谢的关键细胞器之一。在这篇综述中,我们首先简要概述了目前对 H2O2 作为硫醇氧化还原信号转导中的分子信使的认识,以及过氧物酶体作为细胞 H2O2 平衡的守护者和调节者的作用。接下来,我们将重点放在最近发现的源自过氧物酶体的 H2O2 主要蛋白靶标上,强调它们在揭示过氧物酶体 H2O2 与细胞信号之间复杂的相互作用方面的重要性。我们特别关注三个领域:通过过氧化物酶氧化还原中继复合物的信号转导、钙信号转导和磷酸信号转导。最后,我们强调了值得进一步研究的关键研究方向,以加深我们对过氧物酶体 H2O2 代谢改变与疾病相关的分子和生化机制的理解。
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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