Reticulated platelets and coronary slow flow: a study in stable coronary artery disease

S. S. Erdem, Hüseyin Tezcan, Hasan Basri Yıldırım, Zafer Büyükterzi
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Abstract

Abstract Objectives The Coronary Slow Flow (CSF) phenomenon remains a clinical enigma, characterized by delayed opacification of coronary vessels despite angiographically normal or nearly normal arteries. This cross-sectional study explores the potential relationship between reticulated platelets (RPs) and CSF in stable coronary artery disease patients. Methods A total of 200 participants, meeting specific inclusion and exclusion criteria, underwent coronary angiography. Reticulated platelet levels were measured using Sysmex series hematology analyzers. Demographic data, laboratory parameters, and coronary flow velocities were assessed. Results The study comprised 100 individuals with CSF and 100 with normal coronary anatomy. The CSF group exhibited higher rates of diabetes (35 vs. 22 %, p=0.017) and smoking (62 vs. 45 %, p=0.021). Reticulated platelet rates were elevated in the CSF group. However, statistical significance was not reached (p=0.105). Conclusions This study provides insights into the interplay between reticulated platelets and the CSF phenomenon in stable coronary artery disease. Although reticulated platelet levels did not emerge as a major predictor for CSF in this stable phase, the findings contribute to ongoing efforts to understand the multifaceted mechanisms underlying CSF.
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网状血小板与冠状动脉慢血流:对稳定型冠状动脉疾病的研究
摘要 目的 冠状动脉慢流(CSF)现象仍是一个临床谜团,其特点是尽管血管造影显示动脉正常或接近正常,但冠状动脉血管却迟迟不通畅。本横断面研究探讨了稳定型冠心病患者网状血小板(RPs)与 CSF 之间的潜在关系。方法 共有 200 名符合特定纳入和排除标准的参与者接受了冠状动脉造影术。使用 Sysmex 系列血液分析仪测量网状血小板水平。对人口统计学数据、实验室参数和冠状动脉血流速度进行了评估。结果 研究包括 100 名 CSF 患者和 100 名冠状动脉解剖正常的患者。CSF 组的糖尿病(35% 对 22%,P=0.017)和吸烟(62% 对 45%,P=0.021)发病率较高。CSF 组的网状血小板率升高。但统计学意义未达到(P=0.105)。结论 本研究为稳定型冠心病患者网织血小板与 CSF 现象之间的相互作用提供了见解。虽然网织血小板水平并不是预测稳定期 CSF 的主要因素,但研究结果有助于了解 CSF 的多方面机制。
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