Phytochemical, nutraceutical and oxidative stress modulation activities of Solanum villosum Mill. leaf and berry extracts

IF 2.1 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Rendiconti Lincei-Scienze Fisiche E Naturali Pub Date : 2024-01-23 DOI:10.1007/s12210-023-01212-x

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Abstract

The present work depicted the pharmacological and nutritional importance of Solanum villosum Mill. based on its traditional value. It is an ethnomedicinal plant of the family Solanaceae used to treat edema and sore eyes, apart from its use as salad and fruit. Leaves and berries of Solanum villosum were explored for the bioactive compounds, antioxidant activity and nutritional potential. Plant extract of both parts i.e., leaves and berries were prepared in methanol and chloroform solvent, then subjected to analysis. Alkaloids, flavonoids, phenols, saponins, and tannins were quantified as major phytochemicals. Antioxidant activity was tested by DPPH radical scavenging, Phosphomolybdate and reducing power assay. Brine shrimp lethality assay was employed to study cytotoxic activity of extracts. Assessment of nutritional value was done by proximate analysis. Alkaloids and saponins were present in significant quantities i.e., 7.6 mg g⁻¹, 3.48 mg g⁻¹, 5.67 mg g⁻¹, and 1.98 mg g⁻¹ in leaves and berries respectively. Methanol extracts exhibited noticeable antioxidant activity, as compared to chloroform extracts. Higher antioxidant activity of leaves was reported as compared to berries with IC₅₀ values of 196.86 µg mL⁻¹ by Phosphomolybdate assay. Methanol extract of leaves demonstrated promising cytotoxic activity with LD₅₀ value of 74.44 μg mL⁻¹. Results for nutritional analysis indicated presence of carbohydrates, proteins, and crude fiber in both extracts, while protein content was higher in berries. Results of the study suggest that the plant can be utilized as a source of balanced nutraceutical products having benefits of food and medicine.

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Solanum villosum Mill.叶片和浆果提取物的植物化学、营养保健和氧化应激调节活性

摘要本研究根据茄科植物茄属（Solanum villosum Mill.）的传统价值，阐述了其药理和营养方面的重要性。茄科植物茄属（Solanaceae）是一种民族药用植物，除用作沙拉和水果外，还可用于治疗水肿和眼睛疼痛。研究人员对 Solanum villosum 的叶片和浆果进行了生物活性化合物、抗氧化活性和营养潜力方面的探索。在甲醇和氯仿溶剂中制备叶片和浆果的植物提取物，然后进行分析。生物碱、黄酮类、酚类、皂苷和单宁酸是主要的植物化学物质。抗氧化活性通过 DPPH 自由基清除、磷钼酸盐和还原力检测进行测试。盐水虾致死试验用于研究提取物的细胞毒性活性。通过近似分析评估了营养价值。叶片和浆果中含有大量生物碱和皂苷，分别为 7.6 毫克/克-1、3.48 毫克/克-1、5.67 毫克/克-1 和 1.98 毫克/克-1。与氯仿提取物相比，甲醇提取物具有明显的抗氧化活性。通过磷钼酸盐测定，叶片的抗氧化活性高于浆果，IC50 值为 196.86 µg mL-1。叶片的甲醇提取物具有良好的细胞毒性活性，半数致死剂量为 74.44 μg mL-1。营养分析结果表明，两种提取物中都含有碳水化合物、蛋白质和粗纤维，而浆果中的蛋白质含量更高。研究结果表明，该植物可作为具有食品和药品功效的均衡营养保健品的来源。

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来源期刊

Rendiconti Lincei-Scienze Fisiche E Naturali MULTIDISCIPLINARY SCIENCES-

CiteScore

4.10

自引率

10.00%

发文量

审稿时长

>12 weeks

期刊介绍： Rendiconti is the interdisciplinary scientific journal of the Accademia dei Lincei, the Italian National Academy, situated in Rome, which publishes original articles in the fi elds of geosciences, envi ronmental sciences, and biological and biomedi cal sciences. Particular interest is accorded to papers dealing with modern trends in the natural sciences, with interdisciplinary relationships and with the roots and historical development of these disciplines.