Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and ZF2001 booster vaccine.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2024-01-27 DOI:10.1186/s12979-023-00408-x
Yuwei Zhang, Lianxiang Zhao, Jinzhong Zhang, Xiaomei Zhang, Shanshan Han, Qingshuai Sun, Mingxiao Yao, Bo Pang, Qing Duan, Xiaolin Jiang
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Abstract

Background: In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, we detected serum IgG antibodies and PBMC sample transcriptome profiles in 46 participants under 70 years old and 25 participants over 70 years old who received the third dose of the BBIBP-CorV and ZF2001 vaccines.

Results: On day 7, the antibody levels of people over 70 years old after the third dose of booster vaccine were lower than those of young people, and the transcriptional responses of innate and adaptive immunity were also weak. The age of the participants showed a significant negative correlation with functions related to T-cell differentiation and costimulation. Nevertheless, 28 days after the third dose, the IgG antibodies of elderly adults reached equivalence to those of younger adults, and immune-related transcriptional regulation was significantly improved. The age showed a significant positive correlation with functions related to "chemokine receptor binding", "chemokine activity", and "chemokine-mediated signaling pathway".

Conclusions: Our results document that the response of elderly adults to the third dose of the vaccine was delayed, but still able to achieve comparable immune effects compared to younger adults, in regard to antibody responses as well as at the transcript level.

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接种第三剂 COVID-19 BBIBP-CorV 和 ZF2001 强化疫苗的 70 岁以上老年人外周血单核细胞中的抗体和转录图谱。
背景:在 COVID-19 大流行和广泛接种疫苗的背景下,探索老年人对 COVID-19 的同源和异源强化疫苗的免疫反应非常重要。为此,我们检测了接种第三剂 BBIBP-CorV 和 ZF2001 疫苗的 46 名 70 岁以下参与者和 25 名 70 岁以上参与者的血清 IgG 抗体和 PBMC 样本转录组图谱:结果:接种第三剂加强疫苗后第7天,70岁以上老年人的抗体水平低于年轻人,先天性免疫和适应性免疫的转录反应也较弱。参与者的年龄与 T 细胞分化和成本刺激相关功能呈显著负相关。然而,在服用第三剂 28 天后,老年人的 IgG 抗体达到了年轻人的水平,与免疫相关的转录调控也得到了明显改善。年龄与 "趋化因子受体结合"、"趋化因子活性 "和 "趋化因子介导的信号通路 "相关功能呈显著正相关:我们的研究结果表明,老年人对第三剂疫苗的反应有所延迟,但在抗体反应和转录物水平上仍能达到与年轻人相当的免疫效果。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
期刊最新文献
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