Invasive fungal rhinosinusitis by Fusarium proliferatum/annulatum in a patient with acute myeloid leukemia: A case report and review of the literature

IF 2.2 4区医学 Q3 MYCOLOGY Journal de mycologie medicale Pub Date : 2024-01-27 DOI:10.1016/j.mycmed.2024.101461

Zeynep Cansu Caliskan , Gizem Karahan , Neslihan Koray , Yasin Gokcinar , Dolunay Gülmez , Sevtap Arikan-Akdagli , Serhat Unal , Omrum Uzun

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Abstract

Antifungal prophylaxis with a mold-effective agent has led to a substantial decrease in invasive infections caused by Aspergillus spp. in the management of patients with acute myeloid leukemia undergoing induction chemotherapy. However, difficult-to-treat infections caused by other molds, such as Fusarium, Lomentospora, and Scedosporium species may still complicate the neutropenic period. Here, we present a case of a 23-year-old woman with acute myeloid leukemia who developed a breakthrough invasive fungal rhinosinusitis caused by Fusarium proliferatum/annulatum on posaconazole prophylaxis. The infection was diagnosed using clinical, microbiological, and radiological criteria and the isolate was identified using Matrix Assisted Lazer Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) and sequencing. We searched Pubmed with “Fusarium proliferatum”, “Fusarium annulatum”, “immunosuppression AND fusariosis“, “rhinosinusitis AND Fusarium proliferatum” and summarized the English literature for similar rhinosinusitis cases infected with the same pathogen.

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一名急性髓性白血病患者的侵袭性真菌性鼻窦炎（Fusarium proliferatum/annulatum）：病例报告和文献综述

在对接受诱导化疗的急性髓性白血病患者进行治疗时，使用霉菌特效药物进行抗真菌预防可大幅减少由曲霉菌属引起的侵袭性感染。然而，由其他霉菌（如镰刀菌属、洛门冬孢子菌属和角孢子菌属）引起的难以治疗的感染仍可能使中性粒细胞减少期变得复杂。在此，我们介绍了一例 23 岁急性髓性白血病女性患者的病例，她在服用泊沙康唑预防治疗后，出现了由增殖镰刀菌/annulatum 引起的突破性侵袭性真菌鼻炎。感染是通过临床、微生物学和放射学标准确诊的，分离物是通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）和测序鉴定的。我们在 Pubmed 上搜索了 "增殖镰刀菌"、"环状镰刀菌"、"免疫抑制和镰刀菌病"、"鼻炎和增殖镰刀菌"，并总结了感染相同病原体的类似鼻炎病例的英文文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.