The potential of DNA methylation markers in the study of obesity

Q3 Medicine Obesity and Metabolism Pub Date : 2024-01-23 DOI:10.14341/omet13058

A. F. Nikolaeva, K. Petrova, O. Vasyukova, R. M. Guseinova, I. Minniakhmetov, R. Khusainova, N. Mokrysheva, V. Sigin

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Abstract

Obesity is a complex, heterogeneous, actively progressive disease manifested by excessive formation of adipose tissue in the body and usually has a high cardiometabolic risk and specific complications. Currently, new data are emerging that explain the pathogenesis of obesity not only by genetic variations and imbalance between energy intake and expenditure, but also by the influence of epigenetic mechanisms, such as DNA methylation. DNA methylation is the most studied epigenetic modification, whose status in the cell can be altered by various external and internal environmental factors, including diet, lifestyle, and hormones. These changes may lead to dysregulation of genes responsible for metabolic processes associated with the development of obesity. However, studies investigating epigenetic marks as potential mediators of obesity are heterogeneous in design, methodology, and results. This review discusses a conceptual framework analyzing the relationship between DNA methylation, obesity, inflammation, and response to weight loss, including after bariatric surgery, as well as material selection and methodology issues to consider when designing studies in this area.

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DNA 甲基化标记在肥胖症研究中的潜力

肥胖症是一种复杂的、异质性的、主动进展性疾病，表现为体内脂肪组织的过度形成，通常具有较高的心脏代谢风险和特定的并发症。目前，新的数据表明，肥胖症的发病机理不仅与遗传变异和能量摄入与消耗失衡有关，还与 DNA 甲基化等表观遗传机制的影响有关。DNA 甲基化是研究最多的表观遗传修饰，其在细胞中的状态可因饮食、生活方式和激素等各种内外环境因素而改变。这些变化可能会导致负责与肥胖发展相关的代谢过程的基因失调。然而，将表观遗传标记作为肥胖症潜在介导因素进行调查的研究在设计、方法和结果上都不尽相同。本综述讨论了分析 DNA 甲基化、肥胖、炎症和减肥反应（包括减肥手术后）之间关系的概念框架，以及设计该领域研究时应考虑的材料选择和方法问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity and Metabolism Medicine-Internal Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Journal "Obesity and Metabolism" is a multidisciplinary forum for clinical and applied research in the field of biochemistry, physiology, pathophysiology, genetics, nutrition, as well as molecular, metabolic, psychological and epidemiological aspects of obesity and metabolism. The main subject "Metabolism" reviewed in the journal, includes fat, carbohydrate, protein, bone, fluid and electrolyte and other types of metabolism in the spectrum of pathology of the endocrine system. The priority direction of Journal "Obesity and Metabolism" is publishing modern high-quality original research on the effectiveness of new and existing treatments in any aspect of metabolic and endocrine diseases. Pre-clinical pharmacology, pharmacokinetics studies, meta-analyzes, addressed to drug safety and tolerance are also welcome for publication in the journal "Obesity and metabolism." Journal "Obesity and Metabolism" announces review articles that are balanced, clear and offer the reader a modern and critical analysis of the literature on the subject of the magazine. Case reports, and lecture materials are also published for highlighting for practitioners new approaches to diagnosis and treatment of patients with metabolic disorders and obesity.