Engineering of ovarian tissue for ovarian dysfunctions: A review

A. Zhylkybekova, G. Koshmaganbetova, Myltykbay Rysmakhanov, N. Abenova, Nadiar M. Mussin, A. A. Kaliyev, Mahdi Mahdipour, A. Tamadon
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Abstract

This review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases, such as premature ovarian failure or oophorectomy. The loss of ovarian function can lead to infertility, osteoporosis, and cardiovascular disease. Hormone replacement therapy is a common treatment, but it has limitations and risks. The review focuses on two main approaches in tissue engineering: scaffold-based (3D printing, electrospinning, decellularization) and scaffold-free (stem cell transplantation, organoid cultivation). Both approaches show promise in preclinical studies for creating functional ovarian tissue. Challenges include vascularization, innervation, long-term function, and safety. Despite these challenges, tissue engineering offers a potential avenue for restoring fertility and hormone balance in women with ovarian dysfunction.
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治疗卵巢功能障碍的卵巢组织工程:综述
这篇综述探讨了组织工程作为一种潜在的解决方案,如何解决因遗传或后天疾病(如卵巢早衰或卵巢切除术)而导致的女性生殖健康问题。卵巢功能丧失可导致不孕、骨质疏松症和心血管疾病。激素替代疗法是一种常见的治疗方法,但也存在局限性和风险。本综述重点介绍组织工程学的两种主要方法:基于支架(三维打印、电纺丝、脱细胞)和无支架(干细胞移植、类器官培养)。在临床前研究中,这两种方法都显示出创建功能性卵巢组织的前景。面临的挑战包括血管化、神经支配、长期功能和安全性。尽管存在这些挑战,组织工程仍为卵巢功能障碍妇女恢复生育能力和激素平衡提供了一条潜在的途径。
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