Features of cardiovascular magnetic resonance native T1 mapping in maintenance hemodialysis patients and their related factors.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-01-31 DOI:10.1080/0886022X.2024.2310078

Changqin Zhang, Lijing Yao, Min Liu, Yilun Zhou

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Abstract

Purpose: Increased myocardial T1 values on cardiovascular MRI (CMRI) have been shown to be a surrogate marker for myocardial fibrosis. The use of CMRI in patients on hemodialysis (HD) remains limited. This research aimed to explore the characteristics of native T1 values in HD patients and identify factors related to T1 values.

Methods: A total of thirty-two patients on HD and fourteen healthy controls were included in this study. All participants underwent CMRI. Using modified Look-Locker inversion recovery (MOLLI) sequence, native T1 mapping was achieved. Native CMRI T1 values were compared between the two groups. In order to analyze the relationship between T1 values and clinical parameters, correlation analysis was performed in patients on HD.

Results: Patients on HD exhibited elevated global native T1 values compared to control subjects. In the HD group, the global native T1 value correlated positively with intact parathyroid hormone (iPTH) (r = 0.418, p = 0.017) and negatively with triglycerides (r= -0.366, p = 0.039). Moreover, the global native T1 value exhibited a positive correlation with the left ventricular end-diastolic volume indexed to body surface area (BSA; r = 0.528, p = 0.014), left ventricular end-systolic volume indexed to BSA (r = 0.506, p = 0.019), and left ventricular mass indexed to BSA (r = 0.600, p = 0.005). A negative correlation was observed between the global native T1 value and ejection fraction (r = 0.-0.551, p = 0.010).

Conclusion: The global native T1 value was prolonged in HD patients compared with controls. In the HD group, the global T1 value correlated strongly with iPTH, triglycerides, and cardiac structural and functional parameters.

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维持性血液透析患者心血管磁共振原位 T1 图的特征及其相关因素。

目的：心血管磁共振成像（CMRI）上增加的心肌 T1 值已被证明是心肌纤维化的替代标记物。CMRI在血液透析（HD）患者中的应用仍然有限。本研究旨在探索血液透析患者原生 T1 值的特征，并确定与 T1 值相关的因素：本研究共纳入 32 名 HD 患者和 14 名健康对照者。所有参与者均接受了 CMRI 检查。使用改良的 Look-Locker 反转恢复（MOLLI）序列，实现了原生 T1 映射。两组患者的原生 CMRI T1 值进行了比较。为了分析 T1 值与临床参数之间的关系，对接受 HD 治疗的患者进行了相关性分析：结果：与对照组相比，HD 患者的全局原生 T1 值升高。在 HD 组中，全局原生 T1 值与完整甲状旁腺激素（iPTH）呈正相关（r=0.418，p=0.017），与甘油三酯呈负相关（r=-0.366，p=0.039）。此外，全球原生 T1 值与以体表面积（BSA）为指标的左心室舒张末期容积（r = 0.528，p = 0.014）、以 BSA 为指标的左心室收缩末期容积（r = 0.506，p = 0.019）和以 BSA 为指标的左心室质量（r = 0.600，p = 0.005）呈正相关。全局原生 T1 值与射血分数之间呈负相关（r = 0.-0.551，p = 0.010）：结论：与对照组相比，HD 患者的全局原生 T1 值延长。在 HD 组中，全局 T1 值与 iPTH、甘油三酯、心脏结构和功能参数密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.