Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Japanese Dental Science Review Pub Date : 2024-01-25 DOI:10.1016/j.jdsr.2024.01.001

Pan Gao , Mikihito Kajiya , Souta Motoike , Makoto Ikeya , Jingmei Yang

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Abstract

Guided tissue regeneration (GTR) has been widely used in the periodontal treatment of intrabony and furcation defects for nearly four decades. The treatment outcomes have shown effectiveness in reducing pocket depth, improving attachment gain and bone filling in periodontal tissue. Although applying GTR could reconstruct the periodontal tissue, the surgical indications are relatively narrow, and some complications and race ethic problems bring new challenges. Therefore, it is challenging to achieve a consensus concerning the clinical benefits of GTR. With the appearance of stem cell-based regenerative medicine, mesenchymal stem/stromal cells (MSCs) have been considered a promising cell resource for periodontal regeneration. In this review, we highlight preclinical and clinical periodontal regeneration using MSCs derived from distinct origins, including non-odontogenic and odontogenic tissues and induced pluripotent stem cells, and discuss the transplantation procedures, therapeutic mechanisms, and concerns to evaluate the effectiveness of MSCs.

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间充质干细胞/基质细胞在牙周再生中的应用：机遇与挑战

近四十年来，引导组织再生技术（GTR）已被广泛应用于牙周治疗骨内和毛面缺损。治疗结果表明，其在减少牙周袋深度、改善附着增量和牙周组织骨充填方面具有良好的效果。虽然应用 GTR 可以重建牙周组织，但手术适应症相对较窄，一些并发症和种族伦理问题带来了新的挑战。因此，就 GTR 的临床益处达成共识具有挑战性。随着以干细胞为基础的再生医学的出现，间充质干/基质细胞（MSCs）被认为是牙周再生的一种有前景的细胞资源。在这篇综述中，我们重点介绍了利用不同来源的间充质干细胞（包括非牙本质组织和牙本质组织以及诱导多能干细胞）进行牙周再生的临床前和临床研究，并讨论了间充质干细胞的移植程序、治疗机制以及评估其有效性的关注点。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.