Endoscopic resection for residual oesophageal neoplasia after definitive chemoradiotherapy

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Best Practice & Research Clinical Gastroenterology Pub Date : 2024-02-01 DOI:10.1016/j.bpg.2024.101885

Judith Honing, Arjun D. Koch, Peter D. Siersema, Manon Spaander

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Abstract

Definitive chemoradiation is the recommended treatment for locally advanced, irresectable oesophageal cancer and a valid alternative to neoadjuvant chemoradiotherapy (CRT) with surgery in oesophageal squamous cell cancer (OSCC) patients. In case of locoregional recurrence, salvage treatment can be considered in fit and resectable patients. Salvage surgery is a valid option but associated with significant morbidity. Therefore, for tumors confined to the mucosa or submucosal layers endoscopic resection is a good and less-invasive alternative. Over the last decade several case-series have demonstrated a high technical success rate of endoscopic treatment after definitive CRT. In this review we summarize the clinical outcomes and challenges of endoscopic treatment of early recurrence after definitive CRT in oesophageal cancer.

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内镜下切除最终化疗后残留的食道肿瘤

对于局部晚期、不可切除的食道癌，建议采用确定性化放疗，这也是食道鳞状细胞癌（OSCC）患者新辅助化放疗（CRT）和手术的有效替代疗法。如果出现局部复发，身体健康且可切除的患者可考虑进行挽救治疗。挽救性手术是一种有效的选择，但会带来严重的发病率。因此，对于局限于粘膜或粘膜下层的肿瘤，内窥镜切除术是一种良好且创伤较小的替代方法。在过去的十年中，已有多个病例系列证明，在明确的 CRT 治疗后，内镜治疗的技术成功率很高。在这篇综述中，我们总结了食道癌明确 CRT 后早期复发内镜治疗的临床结果和挑战。

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来源期刊

Best Practice & Research Clinical Gastroenterology 医学-胃肠肝病学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.

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