Immunoprotective Effect of Liver Allograft on Patients with Combined Liver and Kidney Transplantation.

IF 1.1 4区 医学 Q3 SURGERY Annals of Transplantation Pub Date : 2024-02-06 DOI:10.12659/AOT.942763
Joon-Young Kim, Hye Bin Kim, Jin-Myung Kim, Hye Eun Kwon, Young Hoon Kim, Youngmin Ko, Frances S Sung, Joo Hee Jung, Chung Hee Baek, Hyosang Kim, Su-Kil Park, Sung Shin, Hyunwook Kwon
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Abstract

BACKGROUND Simultaneous liver-kidney transplantation (SLKT) and kidney transplantation (KT) after liver transplantation (LT) provide potential treatment options for patients with end-stage liver and kidney disease. There is increasing attention being given to liver-kidney transplantation (LTKT), particularly regarding the immune-protective effects of the liver graft. This retrospective, single-center, observational study aimed to evaluate the clinical outcomes of KT in LTKT patients - either SLKT or KT after LT (KALT) - compared to KT alone (KTA). MATERIAL AND METHODS We included patients who underwent KT between January 2005 and December 2020, comprising a total of 4312 patients divided into KTA (n=4268) and LTKT (n=44) groups. The LTKT group included 11 SLKT and 33 KALT patients. To balance the difference in sample sizes between the 2 groups, we performed 3: 1 propensity score matching (PSM). RESULTS There was no significant difference in graft survival between the groups. However, the LTKT group exhibited significantly superior rejection-free survival compared to the KTA group (P.

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肝移植对肝肾联合移植患者的免疫保护作用
背景 肝移植(LT)后同时进行肝肾移植(SLKT)和肾移植(KT)为终末期肝肾疾病患者提供了潜在的治疗选择。人们越来越关注肝肾移植(LTKT),尤其是肝脏移植的免疫保护作用。这项回顾性、单中心观察性研究旨在评估肝肾移植(LTKT)患者的临床疗效(SLKT或LT后KT(KALT))与单纯KT(KTA)的比较。材料和方法 我们纳入了 2005 年 1 月至 2020 年 12 月期间接受 KT 的患者,共计 4312 人,分为 KTA 组(n=4268)和 LTKT 组(n=44)。LTKT 组包括 11 名 SLKT 和 33 名 KALT 患者。为了平衡两组样本量的差异,我们进行了 3:1 倾向评分匹配(PSM)。结果 两组的移植物存活率无明显差异。但是,与 KTA 组相比,LTKT 组的无排斥反应存活率明显更高(P.
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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
79
审稿时长
>12 weeks
期刊介绍: Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation. Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication. Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.
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