The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex^® - A Cannabis-derived Spray.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-01-01 DOI:10.2174/0113895575285934240123110158

Sina Motamedy, Bahareh Soltani, Halimeh Kameshki, Asmae Alipour Kermani, Reza Saboori Amleshi, Masoud Nazeri, Mohammad Shabani

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Abstract

Sativex is a cannabis-based medicine that comes in the form of an oromucosal spray. It contains equal amounts of Δ9-tetrahydrocannabinol and cannabidiol, two compounds derived from cannabis plants. Sativex has been shown to have positive effects on symptoms of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and sleep disorders. It also has analgesic, antiinflammatory, antitumoral, and neuroprotective properties, which make it a potential treatment option for other neurological disorders. The article reviews the results of recent preclinical and clinical studies that support the therapeutic potential of Sativex and the molecular mechanisms behind its neuroprotective benefits in various neurological disorders. The article also discusses the possible advantages and disadvantages of using Sativex as a neurotherapeutic agent, such as its safety, efficacy, availability, and legal status.

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Sativex® - 一种大麻衍生喷雾剂的治疗潜力及其神经保护作用的分子机制。

Sativex 是一种口腔喷雾形式的大麻药物。它含有等量的Δ9-四氢大麻酚和大麻二酚，这是两种从大麻植物中提取的化合物。Sativex 已被证明对肌萎缩性脊髓侧索硬化症（ALS）、多发性硬化症（MS）和睡眠障碍等症状有积极作用。它还具有镇痛、抗炎、抗肿瘤和神经保护特性，因此是治疗其他神经系统疾病的潜在选择。文章回顾了支持 Sativex 治疗潜力的最新临床前和临床研究结果，以及 Sativex 在各种神经系统疾病中具有神经保护作用的分子机制。文章还讨论了将 Sativex 用作神经治疗剂可能存在的利弊，如其安全性、有效性、可用性和法律地位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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